Condition
Aromatase-Inhibitor Related Joint Pain
Aromatase-inhibitor joint pain is aching and stiffness in the hands, wrists, knees and feet that affects many women taking these breast cancer medicines, and it is thought to stem from the drop in estrogen affecting joints and cartilage. Vitamin D and omega-3 fatty acids are the supplements most often looked at for it, but little research on them has been reviewed here so far. Because of that, it is too early to say how much either one helps.
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 1
- People studied
- 290
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Pain | Improves (the measure goes down) | 2 studies | 290 people | |||
The Aromatase Inhibitor-Related Joint Pain Support protocol
2 primary supplements · 5 supporting supplements
- Vitamin D2,000–4,000 IU daily (target 40–60 ng/mL; higher doses if deficient)
- Omega-3 Fatty Acids3–4 g EPA+DHA daily
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Aromatase-Inhibitor Related Joint Pain. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
2 studies from PubMed