Condition
Beta-Thalassemia/Hb E
Beta-thalassemia is an inherited blood disorder in which the body makes abnormal hemoglobin, leading to anemia of varying severity, including the Hb E form common in Southeast Asia. The evidence is strongest for vitamin D and calcium, which support bones at risk from osteoporosis, a major complication. Curcumin is far less studied: one small study of 21 people found antioxidant enzyme levels went up, but the evidence is limited.
- Supplements studied
- 1
- Graded outcomes
- 1
- Trials
- 1
- People studied
- 21
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anti-Oxidant Enzyme Profile Moderate Increase | Improves (the measure goes up) | Moderate effect | 21 people | |||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 6 studies | 21 people | |||
Studies that measured oxidative stress biomarkers
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Key findings
- Anti-Oxidant Enzyme ProfileImproves (the measure goes up)
The Beta-Thalassemia/Hb E Supportive Care protocol
2 primary supplements · 8 supporting supplements
Studies cited
6 studies from PubMed
- Efficacy of antioxidant intervention and exercise intervention for lipid peroxidation in dialysis patients: a meta-analysis.
- Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease
- Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids
- Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal
- Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
- The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.