Condition
Eisenmenger Syndrome
Eisenmenger syndrome is a complication of an untreated large hole in the heart, where years of extra blood flow stiffen the lung vessels until pressure rises and oxygen-poor blood crosses into the body's circulation. Iron is rated moderate for this condition and citrulline limited, and small studies of citrulline found blood pressure came down. Those studies involved only about 25 people in total, so the findings are early.
Sources: PMID 31889969; PMID 21154265
- Supplements studied
- 1
- Graded outcomes
- 1
- Trials
- 1
- People studied
- 25
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood Pressure Small Improvement | Improves (the measure goes down) | Small effect | 7 studies | 25 people | ||
Studies that measured blood pressure
| ||||||
| Exercise Capacity | Improves (the measure goes up) | 25 people | ||||
Key findings
- Blood PressureImproves (the measure goes down)
The Eisenmenger Syndrome Supportive Care protocol
1 primary supplement · 5 supporting supplements
- IronBased on iron studies - guided by pulmonary hypertension specialist (target ferritin >50 ng/mL)
Studies cited
7 studies from PubMed
- Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline
- Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial
- Acute Effects of Citrulline Malate Supplementation on Nocturnal Blood Pressure Dipping After Exercise in Hypertensive Patients: A Randomized, Placebo-Controlled Trial.
- Inter-Individual Responses to Citrulline Malate Oral Supplementation on Post-Exercise Hypotension in Hypertensives: A 24-Hour Analysis
- Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction
- Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation
- Effect of oral L-citrulline on brachial and aortic blood pressure defined by resting status: evidence from randomized controlled trials