Condition
General Health
General health is the overall state of your body and mind, shaped by how well your organs, hormones, immune defenses and everyday metabolism work together. Tyrothricin, an antibiotic mixture, has the strongest evidence here, and the finding was a warning: across four studies, systemic use caused toxicity, including red blood cell breakdown and kidney damage. Its use has stayed limited to topical and local applications, and its toxicity resembles that of gramicidin, one of its components.
Sources: PMID 17462586
- Updated
- How we grade
- 3 studies cited
- Supplements studied
- 0
- Medicines and peptides
- 1
- Graded outcomes
- 1
Prescription medicines and peptides studied, for context
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Systemic Toxicity SAFETY CONCERN: Systemic administration causes significant toxicity - hemolysis and nephrotoxicity. Use restricted to topical and local applications. Similar toxicity profile to component gramicidin. | Worsens (the measure goes up) | Large effect | 3 studies | |||
Studies that measured systemic toxicity
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Key findings
- Systemic ToxicityWorsens (the measure goes up)
Safety notes in the studies
- SAFETY CONCERN: Systemic administration causes significant toxicity - hemolysis and nephrotoxicity.
- Similar toxicity profile to component gramicidin.
Studies cited
3 studies from PubMed
- Reduction of Inflammatory and Noninflammatory Lesions with Topical Tyrothricin 0.1% in the Treatment of Mild to Severe Acne Papulopustulosa: A Randomized Controlled Clinical Trial.
- Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis
- Tyrothricin, a review of selected literature on the subject.