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Condition

Prader-Willi Syndrome (PWS)

Prader-Willi syndrome is a genetic condition caused by missing or inactive genes on chromosome 15, affecting about 1 in 15,000 births and touching appetite, muscle tone, growth, and bone health. Little research on supplements for it has been reviewed here so far, so there are no trial findings to report. Vitamin D and calcium are the most discussed because bone thinning is common, but that rests on their general role in bone health rather than on results in people with this condition.

Supplements studied
1
Graded outcomes
0
Trials
1
People studied
26

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

1 supplement

Coenzyme Q10

Coenzyme Q10: outcomes studied for Prader-Willi Syndrome (PWS)
GradeOutcomeEffectSizeStudiesPeopleStudies list
Prader-Willi Syndrome SymptomsImproves (the measure goes down)1 study26 people

Studies that measured prader-willi syndrome symptoms

The Prader-Willi Syndrome Supportive Care protocol

2 primary supplements · 5 supporting supplements

  • Vitamin D1,000–2,000 IU daily (adjust based on levels)
  • Calcium1,000–1,200 mg daily from diet and supplements

See the full protocol

Studies cited

1 study from PubMed

  1. Developmental profiles in young children with Prader-Labhart-Willi syndrome: effects of weight and therapy with growth hormone or coenzyme Q10Am J Med Genet A · PMID 18257095

Supplement stack for Prader-Willi Syndrome (PWS)