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Staphylococcal Bacteremia and Endocarditis

Staphylococcal bacteremia means Staphylococcus bacteria have entered the bloodstream, and endocarditis is an infection of the heart's inner lining or valves. The strongest evidence is for daptomycin, an intravenous antibiotic: in 246 people, treatment success at 42 days was similar to standard therapy, and adding a second antibiotic did not improve outcomes. It matched standard care rather than beating it, and the endocarditis results covered right-sided infections.

Sources: PMID 16914701

Supplements studied
0
Medicines and peptides
1
Graded outcomes
2
No supplement studies yetWe haven’t found supplement studies for Staphylococcal Bacteremia and Endocarditis. The medicines and peptides studied for it are listed below.

Prescription medicines and peptides studied, for context

These are not supplements. Most need a prescription, and some are research compounds with no approved use.

1 medicine or peptide

Daptomycin (Cubicin)

Daptomycin (Cubicin): outcomes studied for Staphylococcal Bacteremia and Endocarditis
GradeOutcomeEffectSizeStudiesPeopleStudies list
Bacteremia/Endocarditis Cure

Fowler NEJM 2006 (n=246): Treatment success at 42 days 44.2% vs 41.7% standard therapy (noninferiority met). 6 mg/kg IV daily. Effective for both MRSA and MSSA right-sided endocarditis. CAMERA2 trial: Adding beta-lactam did not improve outcomes vs daptomycin alone.

NoneNo effect17 studies

Studies that measured bacteremia/endocarditis cure

and 14 more on the Daptomycin (Cubicin) page

Nephrotoxicity vs Standard Therapy

Fowler NEJM 2006: Clinically significant renal dysfunction 11.0% daptomycin vs 26.3% standard therapy (vancomycin+gentamicin), P=0.004. Significant renal-sparing advantage. Does not require renal dose adjustment until CrCl <30 mL/min.

Improves (the measure goes down)Large effect16 studies

Studies that measured nephrotoxicity vs standard therapy

and 13 more on the Daptomycin (Cubicin) page

Key findings

  • Bacteremia/Endocarditis CureDaptomycin (Cubicin)
  • Nephrotoxicity vs Standard TherapyDaptomycin (Cubicin)Improves (the measure goes down)

Studies cited

18 studies from PubMed

  1. Daptomycin treatment for persistent bacteremia in a pediatric solid organ transplant recipient: Case report and literature review.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2025 · PMID 39216593
  2. Daptomycin as an option for lock therapy: a systematic literature review.Future microbiology, 2023 · PMID 37622290
  3. Daptomycin for the treatment of acute bacterial meningitis: A narrative review.International journal of antimicrobial agents, 2023 · PMID 36870402
  4. Daptomycin synergistic properties from in vitro and in vivo studies: a systematic review.The Journal of antimicrobial chemotherapy, 2022 · PMID 36227704
  5. Efficacy and safety of daptomycin: systematic review and meta-analysisJ Glob Antimicrob Resist, 2020 · PMID 32082568
  6. Effect of vancomycin or daptomycin with vs without an antistaphylococcal β-lactam on mortality, bacteremia, relapse, or treatment failure in patients with MRSA bacteremia: A randomized clinical trialJAMA, 2020 · PMID 32044943
  7. Daptomycin versus linezolid for treatment of vancomycin-resistant enterococcal bacteremia: systematic review and meta-analysis.BMC infectious diseases, 2014 · PMID 25495779
  8. Daptomycin: a review 4 years after first approval.Pharmacology, 2008 · PMID 17940348
  9. Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureusN Engl J Med, 2006 · PMID 16914701
  10. Ketogenic diets for drug-resistant epilepsy.Cochrane Database Syst Rev · PMID 32588435
  11. Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis.JAMA Pediatr · PMID 36716045
  12. The efficacy of phenotropil in the complex treatment of epilepsyZh Nevrol Psikhiatr Im S S Korsakova · PMID 18646385
  13. Vitamins for epilepsy.Cochrane Database Syst Rev · PMID 15846704
  14. The efficacy of cannabidiol for seizures reduction in pharmacoresistant epilepsy: a systematic review and meta-analysis.Acta Epileptol · PMID 40217555
  15. Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complexEpilepsia · PMID 27696387
  16. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trialLancet Neurol · PMID 26724101
  17. Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut SyndromeN Engl J Med · PMID 29768152
  18. The effect of thymoquinone on intractable pediatric seizures (pilot study)Epilepsy Res · PMID 21112742