Supplement

Anatabine

Anatabine is a minor alkaloid found in tobacco and other nightshade plants, chemically related to nicotine and sold as a supplement. The research on it is very limited so far: a small study of 20 people found no clear difference in blood pressure or heart rate. That trial was placebo-controlled and mainly looked at markers of muscle damage, so it says little about other reasons people try anatabine.

Sources: PMID 23875823

Updated 30 September 2026
How we grade
1 study cited

Best evidence: Grade D
Conditions studied: 4
Outcomes: 17
Graded outcomes: 0005

Evidence by condition

Strong
Moderate
Limited
Very limited

4 conditions

Muscle Size Strength

Muscle Size Strength: outcomes studied for Anatabine
Grade	Outcome	Size	Studies	People
	Heart Rate No effect	NoneNo effect	1 study	20 people
Studies that measured heart rate The effects of anatabine on non-invasive indicators of muscle damage: a randomized, double-blind, placebo-controlled, crossover studyJ Int Soc Sports Nutr · PMID 23875823
	Blood Pressure No effect	NoneNo effect		20 people

Muscle Recovery

Muscle Recovery: outcomes studied for Anatabine
Grade	Outcome	Effect	Size	Studies	People
	Blood Pressure No effect		NoneNo effect		20 people
	Heart Rate	Changes; see studies		1 study	20 people
Studies that measured heart rate The effects of anatabine on non-invasive indicators of muscle damage: a randomized, double-blind, placebo-controlled, crossover studyJ Int Soc Sports Nutr · PMID 23875823
	Muscle Damage	Changes; see studies			20 people
	Muscle Soreness	Changes; see studies			20 people
	Power Output	Improves (the measure goes up)			20 people

General Athletic Performance

Blood Pressure
Heart Rate: changes; see studies
Muscle Damage: changes; see studies

General Athletic Performance: outcomes studied for Anatabine
Grade	Outcome	Effect	Size	Studies	People
	Blood Pressure No effect		NoneNo effect		20 people
	Heart Rate	Changes; see studies		1 study	20 people
Studies that measured heart rate The effects of anatabine on non-invasive indicators of muscle damage: a randomized, double-blind, placebo-controlled, crossover studyJ Int Soc Sports Nutr · PMID 23875823
	Muscle Damage	Changes; see studies			20 people
	Muscle Soreness	Changes; see studies			20 people
	Power Output	Improves (the measure goes up)			20 people

Muscle Size & Strength

Blood Pressure
Heart Rate: changes; see studies
Muscle Damage: changes; see studies

Muscle Size & Strength: outcomes studied for Anatabine
Grade	Outcome	Effect	Size	Studies	People
	Blood Pressure No effect		NoneNo effect		20 people
	Heart Rate	Changes; see studies		1 study	20 people
Studies that measured heart rate The effects of anatabine on non-invasive indicators of muscle damage: a randomized, double-blind, placebo-controlled, crossover studyJ Int Soc Sports Nutr · PMID 23875823
	Muscle Damage	Changes; see studies			20 people
	Muscle Soreness	Changes; see studies			20 people
	Power Output	Improves (the measure goes up)			20 people

Key findings

Heart Rate
Blood Pressure

Studies cited

1 study from PubMed

The effects of anatabine on non-invasive indicators of muscle damage: a randomized, double-blind, placebo-controlled, crossover studyJ Int Soc Sports Nutr · PMID 23875823