Supplement
Brassaiopsis glomerulata is a tree in the ginseng plant family, containing triterpene saponins, plant compounds that can interact with enzymes. Lab work has focused on aromatase, an enzyme that helps make estrogen, and saponins from the plant blocked it in cell-free and cell-based tests, though the evidence is very limited. No animal or human studies exist, and blocking an enzyme in a dish often fails to carry over to the body.
- Updated
- How we grade
- Best evidence
- Grade D
- Conditions studied
- 0
- Outcomes
- 1
- Graded outcomes
- 0001
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
General
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Aromatase Inhibition In vitro studies identified triterpene saponins from Brassaiopsis glomerulata that inhibited aromatase enzyme activity in cell-free and cell-based assays. No animal or human studies exist, and in vitro aromatase inhibition frequently fails to translate to in vivo activity due to bioavailability and pharmacokinetic barriers. | Changes; see studies | Small effect |
Key findings
- Aromatase InhibitionChanges; see studies