| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Body Fat Accumulation Two animal studies showed anti-obesity effects with evodiamine supplementation. However, the mechanism may involve TRPV1-mediated heat perception rather than true increases in caloric expenditure. Poor oral bioavailability limits translational relevance to humans. | Improves (the measure goes down) | Small effect | 2 studies | |||
Studies that measured body fat accumulation | ||||||
Supplement
Evodia rutaecarpa is a fruit used in traditional Chinese medicine, and its main compound, evodiamine, activates the same heat-sensing receptor as chili peppers. In lab studies, evodiamine slowed the growth of colon and kidney cancer cells and pushed them toward self-destruction, but the evidence is very limited. No human cancer trials exist, and a rat study found evodiamine is poorly absorbed by mouth.
Sources: PMID 26503233; PMID 16681034
- Updated
- How we grade
- 9 studies cited
- Best evidence
- Grade D
- Conditions studied
- 1
- Outcomes
- 5
- Graded outcomes
- 0005
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
General
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Tumor Cell Proliferation Multiple in vitro studies show evodiamine inhibits proliferation and induces apoptosis across colon cancer, renal carcinoma, and other cell lines via topoisomerase I inhibition, G2/M cell cycle arrest, and IGF-1/HIF-1α downregulation. Novel evodiamine derivatives have been synthesized to improve potency. No human cancer trials exist. | Changes; see studies | Moderate effect | 8 studies | |||
Studies that measured tumor cell proliferation
| ||||||
| Inflammatory Markers In vitro and animal studies demonstrate evodiamine strongly inhibits prostaglandin E2 synthesis, COX-2 induction, and NF-κB activation. Traditional use in Chinese medicine for inflammatory GI complaints supports the mechanism, but no controlled human trials have been conducted. | Improves (the measure goes down) | Moderate effect | 3 studies | |||
Studies that measured inflammatory markers | ||||||
| Cold Sensitivity Evodiamine is a TRPV1 receptor agonist (the same target as capsaicin), producing a warming sensation and reducing perception of cold in mechanistic and animal studies. Traditional use in Chinese medicine centers on warming effects for cold-related conditions. No controlled human data is available. | Changes; see studies | Small effect | 2 studies | |||
| Oral Bioavailability Pharmacokinetic study in rats demonstrated poor oral bioavailability of evodiamine with rapid metabolism, suggesting that oral supplement dosing may not achieve therapeutically relevant plasma concentrations. This is a significant limitation for all proposed therapeutic applications. | Changes; see studies | Large effect | 2 studies | |||
Key findings
- Tumor Cell ProliferationChanges; see studies
- Inflammatory MarkersImproves (the measure goes down)
- Body Fat AccumulationImproves (the measure goes down)
Studies cited
9 studies from PubMed
- Evodiamine: A extremely potential drug development candidate of alkaloids from Evodia rutaecarpa
- Immobilized cells on microcarriers for efficient and biomimetic screening of active compounds acting on FGFR4 from Fructus evodiae.
- Design, synthesis and bioactivity evaluation of novel N-phenyl-substituted evodiamine derivatives as potent anti-tumor agents.
- Untargeted LC-MS/MS-Based Multi-Informative Molecular Networking for Targeting the Antiproliferative Ingredients in Tetradium ruticarpum Fruit.
- Cytological Assessments and Transcriptome Profiling Demonstrate that Evodiamine Inhibits Growth and Induces Apoptosis in a Renal Carcinoma Cell Line.
- Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1α downregulation.
- Evodiamine: a novel anti-cancer alkaloid from Evodia rutaecarpa.
- Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms
- Pharmacological properties of galenical preparation. XVI. Pharmacokinetics of evodiamine and the metabolite in rats.