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Haninjin

Haninjin is an extract of Artemisia iwayomogi, a Korean medicinal herb whose plant compounds, including coumarins and polysaccharides, appear to calm inflammatory signaling in cells. The best-studied area is allergic response, where rodent studies found the extract dampened anaphylactic reactions and allergic airway inflammation, partly by steadying mast cells that release histamine. Nearly all the work so far was in mice, rats, or cell cultures, so the evidence is very limited and says little yet about people.

Sources: PMID 15618130; PMID 16997791

Best evidence
Grade D
Conditions studied
5
Outcomes
7
Graded outcomes
0007

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

5 conditions, plus general outcomes

Allergic Diseases (General)

Allergic Diseases (General): outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Allergic Response

In rodent models, Artemisia iwayomogi extract dose-dependently inhibited systemic anaphylactic reactions (compound 48/80-induced in ICR mice), passive cutaneous anaphylaxis (Sprague-Dawley rats), and ovalbumin-induced allergic airway inflammation (BALB/c mice). Mechanisms include mast cell stabilization via NF-kappaB/p38 MAPK inhibition, reduced histamine release, and suppression of Th2 cytokines and serum IgE. No human studies exist.

Improves (the measure goes down)Moderate effect7 studies

Studies that measured allergic response

Body Composition

Body Composition: outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Fat Mass

Three independent mouse studies showed A. iwayomogi extract attenuated high-fat diet-induced obesity. The extract acts as a direct PPARdelta ligand activating skeletal muscle fatty acid oxidation (n=9/group), suppresses adipogenic transcription factors PPARgamma2/C/EBPalpha reducing visceral adiposity and insulin resistance (n=10/group), and dose-dependently improves hypertriglyceridemia via adiponectin-AMPK pathway activation (n=8/group). All evidence is preclinical.

Improves (the measure goes down)Moderate effect7 studies

Studies that measured fat mass

General

  • Liver Fibrosis: improves
  • Cancer Cell Proliferation: changes; see studies
General: outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Liver Fibrosis

In rat models of CCl4-induced hepatic fibrosis and bile duct ligation cholestasis, A. iwayomogi at 25-50 mg/kg significantly reduced serum ALT/AST, hepatic collagen accumulation, and fibrogenic markers (TGF-beta, PDGF, alpha-SMA). Mechanisms involve enhanced antioxidant capacity (glutathione, SOD) and hepatic stellate cell deactivation. Notably, A. capillaris showed no benefit in the same CCl4 model. No human data.

Improves (the measure goes down)Moderate effect7 studies

Studies that measured liver fibrosis

Cancer Cell Proliferation

In vitro, essential oil from A. iwayomogi induced apoptosis in KB human oral epidermoid carcinoma cells via MAPK-mediated mitochondrial dysfunction and caspase activation. A polysaccharide fraction (AIP1) showed immunomodulatory activity suppressing thymocyte apoptosis, with earlier reports of transplanted tumor growth suppression in mice. Evidence is limited to cell culture with no in vivo tumor studies using the whole extract.

Changes; see studiesSmall effect6 studies

Studies that measured cancer cell proliferation

Alzheimer’s Disease

  • Neuroinflammation: improves
Alzheimer’s Disease: outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Neuroinflammation

In 5xFAD transgenic Alzheimer's mice, A. iwayomogi extract improved cognitive function in Morris Water Maze tests, reduced amyloid-beta burden, and suppressed glial overactivation via AKT/autophagy-lysosomal pathways (n=12-18/group). Separately, the isolated compound yomogin (5 mg/kg) suppressed LPS-induced neuroinflammation in mice by inhibiting JNK/ERK/p38 MAPK phosphorylation (n=5/group). All preclinical.

Improves (the measure goes down)Small effect5 studies

Studies that measured neuroinflammation

Asthma

  • Asthma Symptoms: improves
Asthma: outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Asthma Symptoms

In an ovalbumin-induced allergic asthma model in BALB/c mice, the carbohydrate fraction AIP1 from A. iwayomogi significantly reduced pulmonary eosinophilia, Th2-type cytokine expression, serum IgE levels, and TNF-alpha expression. The mechanism involved decreased dendritic cell surface expression of CD11c and MHC II. Single preclinical study only.

Improves (the measure goes down)Small effect5 studies

Studies that measured asthma symptoms

Bone Health

  • Bone Resorption: improves
Bone Health: outcomes studied for Haninjin
GradeOutcomeEffectSizeStudiesPeopleStudies list
Bone Resorption

In vitro, scopoletin and scopolin (coumarins isolated from A. iwayomogi) suppressed RANKL-induced osteoclast differentiation in RAW 264.7 macrophage cells by scavenging intracellular ROS and superoxide anions during osteoclastogenesis. Single in vitro study with no animal or human follow-up.

Improves (the measure goes down)Small effect5 studies

Studies that measured bone resorption

Key findings

  • Allergic ResponseAllergic Diseases (General)Improves (the measure goes down)
  • Fat MassBody CompositionImproves (the measure goes down)
  • Liver FibrosisImproves (the measure goes down)

Studies cited

17 studies from PubMed

  1. Development of real-time PCR based molecular markers for two medicinal herb Artemisia species A. capillaris and A. iwayomogiFood Science and Biotechnology, 2023 · PMID 36606092
  2. Yomogin, Isolated from Artemisia iwayomogi, Inhibits Neuroinflammation Stimulated by Lipopolysaccharide via Regulating MAPK Pathway.Antioxidants, 2022 · PMID 36670968
  3. Artemisia iwayomogi (Dowijigi) inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppressing the NF-κB signaling pathway.Experimental and Therapeutic Medicine, 2020 · PMID 32104280
  4. Artemisia iwayomogi extract attenuates high-fat diet-induced hypertriglyceridemia in mice: potential involvement of the adiponectin-AMPK pathway and very low density lipoprotein assembly in the liverInternational Journal of Molecular Sciences, 2017 · PMID 28805698
  5. Artemisia iwayomogi extract attenuates high-fat diet-induced obesity by decreasing the expression of genes associated with adipogenesis in miceEvidence-Based Complementary and Alternative Medicine, 2013 · PMID 23401719
  6. Scopoletin and scopolin isolated from Artemisia iwayomogi suppress differentiation of osteoclastic macrophage RAW 264.7 cells by scavenging reactive oxygen species.Journal of Natural Products, 2013 · PMID 23510022
  7. An ethanol extract of Artemisia iwayomogi activates PPARdelta leading to activation of fatty acid oxidation in skeletal musclePLoS One, 2012 · PMID 22479450
  8. Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model.Journal of Ethnopharmacology, 2012 · PMID 22265746
  9. Aqueous extract of Artemisia iwayomogi attenuates cholestatic liver fibrosis in a rat modelFood and Chemical Toxicology, 2012 · PMID 22824087
  10. MAPK activation is necessary to the apoptotic death of KB cells induced by the essential oil isolated from Artemisia iwayomogi.Journal of Ethnopharmacology, 2009 · PMID 19429377
  11. A carbohydrate fraction AIP1 from Artemisia iwayomogi suppresses pulmonary eosinophilia and Th2-type cytokine production in an ovalbumin-induced allergic asthma modelInternational Immunopharmacology, 2008 · PMID 18068107
  12. Application of the multiplex PCR method for discrimination of Artemisia iwayomogi from other Artemisia herbsBiological & Pharmaceutical Bulletin, 2008 · PMID 18379063
  13. Artemisia iwayomogi inhibits immediate-type allergic reaction and inflammatory cytokine secretion.Immunopharmacology and Immunotoxicology, 2006 · PMID 16997791
  14. Development of SCAR marker for discrimination of Artemisia princeps and A. argyi from other Artemisia herbsBiological & Pharmaceutical Bulletin, 2006 · PMID 16595892
  15. Anti-allergic effect of Artemisia iwayomogi on mast cell-mediated anaphylaxisExperimental Biology and Medicine, 2005 · PMID 15618130
  16. AIP1, a water-soluble fraction from Artemisia iwayomogi, suppresses thymocyte apoptosis in vitro and down-regulates the expression of Fas gene.Biological & Pharmaceutical Bulletin, 2005 · PMID 15863908
  17. Inhibition of CCl4-induced liver fibrosis by Artemisia iwayomogiNot specified, 2000 · PMID 10933139