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Palmitoylethanolamide

Palmitoylethanolamide, often called PEA, is a fatty compound your body makes naturally, where it helps calm irritated nerves and regulate inflammation and pain signaling. People have looked at it for menstrual cramps, but the one small trial reviewed here, with 67 participants, found no clear difference in pain compared with placebo. That evidence is very limited, so it says little about how PEA works for other kinds of pain or over longer periods.

Sources: PMID 39910730

Best evidence
Grade D
Conditions studied
1
Outcomes
1
Graded outcomes
0001

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

1 condition

Primary Dysmenorrhea (Menstrual Cramps)

Primary Dysmenorrhea (Menstrual Cramps): outcomes studied for Palmitoylethanolamide
GradeOutcomeEffectSizeStudiesPeopleStudies list
Pain

No effect

NoneNo effect1 study67 people

Studies that measured pain

Key findings

  • PainPrimary Dysmenorrhea (Menstrual Cramps)

Studies cited

1 study from PubMed

  1. Palmitoylethanolamide (Levagen+) for acute menstrual pain: a randomized, crossover, double-blind, placebo-controlled trial.Women Health · PMID 39910730

Protocols that include Palmitoylethanolamide