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PRL-8-53

PRL-8-53 is a synthetic compound, not a nutrient, that researchers have explored for its possible effects on how the brain handles learning and recall. People mostly look at it for cognitive improvement, and the evidence is limited: in research with 47 people, memory improved. That is a small group, and motor control showed no clear difference, so the picture is far from settled.

Best evidence
Grade C
Conditions studied
1
Outcomes
4
Graded outcomes
0011

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

1 condition

Cognitive Improvement: outcomes studied for PRL-8-53
GradeOutcomeEffectSizeStudiesPeopleStudies list
Memory

Moderate Improvement

Improves (the measure goes up)Moderate effect47 people
Motor Control

No effect

NoneNo effect47 people
Working MemoryImproves (the measure goes up)1 study47 people
Reaction TimeImproves (the measure goes up)47 people

Key findings

  • MemoryCognitive ImprovementImproves (the measure goes up)
  • Motor ControlCognitive Improvement

Studies cited

1 study from PubMed

  1. PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agentPsychopharmacology · PMID 418433