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Trehalose

Trehalose is a natural sugar made of two linked glucose molecules, found in mushrooms, yeast and some plants, where it helps cells withstand drying and oxidative stress. Most people look at it for dry eye, and the evidence is moderate: in two trials of eye drops, dry eye symptoms improved. Those studies were small, involving only 70 people in total, so the findings are early and say little about long-term use.

Sources: PMID 12414409; PMID 15295655

Best evidence
Grade B
Conditions studied
1
Outcomes
1
Graded outcomes
0100

Evidence by condition

  • Strong
  • Moderate
  • Limited
  • Very limited

1 condition

Dry Eye: outcomes studied for Trehalose
GradeOutcomeEffectSizeStudiesPeopleStudies list
Dry Eye Symptoms

Large Improvement

Improves (the measure goes down)Large effect2 studies70 people

Studies that measured dry eye symptoms

Key findings

  • Dry Eye SymptomsDry EyeImproves (the measure goes down)

Studies cited

2 studies from PubMed

  1. Trehalose eye drops in the treatment of dry eye syndromeOphthalmology · PMID 12414409
  2. Trehalose versus hyaluronan or cellulose in eyedrops for the treatment of dry eyeJpn J Ophthalmol · PMID 15295655