Condition
Acute Kidney Injury
Acute kidney injury is a sudden drop in kidney function over hours to days, often after reduced blood flow, direct kidney damage, or a urinary blockage. Vitamin E has moderate evidence, with fewer cases of kidney injury reported, and among people in shock, angiotensin II was linked to more coming off dialysis and surviving 28 days. That angiotensin II result came from a follow-up analysis still needing confirmation.
- Supplements studied
- 6
- Medicines and peptides
- 1
- Graded outcomes
- 7
- People studied
- 580
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Hyperphosphatemia Management in CKD Multiple human clinical studies in CKD and dialysis patients demonstrate that dietary phosphorus restriction and modified cooking methods effectively reduce serum phosphorus levels. Improving diet recipes and cooking methods attenuated hyperphosphatemia in peritoneal dialysis patients. Very low protein diets supplemented with keto-analogues also reduced phosphorus burden. | Improves (the measure goes up) | Moderate effect | 5 studies | |||
Studies that measured hyperphosphatemia management in ckd | ||||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Acute Kidney Injury Incidence Moderate Improvement | Improves (the measure goes down) | Moderate effect | 357 people | |||
| Creatinine | Improves (the measure goes up) | 1 study | 478 people | |||
Studies that measured creatinine | ||||||
| Kidney Function | Improves (the measure goes up) | 425 people | ||||
Valine
- Plasma BCAA Levels in Renal Insufficiency: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Plasma BCAA Levels in Renal Insufficiency Studies in patients with chronic renal insufficiency show altered BCAA metabolism including valine. A randomized crossover study found BCAA-enriched dialysis fluid improved plasma BCAA concentrations. Keto acid-amino acid supplements influenced BCAA metabolism in CKD patients on low-protein diets. | Improves (the measure goes up) | Small effect | 5 studies | 40 people | ||
Studies that measured plasma bcaa levels in renal insufficiency | ||||||
Danshen
- Kidney Injury Risk: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Kidney Injury Risk In a rat model, tanshinone IIA attenuated contrast-induced nephropathy via Nrf2 antioxidant pathway activation (PMID:29763899). A network pharmacology study with experimental validation explored mechanisms of the danshen-containing formula Shenkang in chronic kidney disease (PMID:31386888). Human clinical data for renal protection is absent. | Improves (the measure goes down) | Small effect | 2 studies | |||
Chaga
- Kidney Damage Risk (Oxalate Nephropathy): worsens
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Kidney Damage Risk (Oxalate Nephropathy) A case report documented chaga mushroom-induced oxalate nephropathy presenting as nephrotic syndrome. Chaga contains high levels of oxalates, and excessive consumption may cause kidney injury. This is an adverse effect warranting caution. | Worsens (the measure goes up) | Moderate effect | 1 study | 1 person | ||
Studies that measured kidney damage risk (oxalate nephropathy) | ||||||
East Indian globe thistle
- Nephroprotection (Drug-Induced Kidney Injury): improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Nephroprotection (Drug-Induced Kidney Injury) In a rat model of cisplatin-induced nephrotoxicity, ethanol extract of S. indicus (150 and 300 mg/kg) significantly reduced elevated serum creatinine and urea levels, restored renal antioxidant enzymes (SOD, catalase, GPx, GSH), and reduced lipid peroxidation. Effects attributed to the plant's antioxidant potential. | Improves (the measure goes down) | Moderate effect | 1 study | |||
Studies that measured nephroprotection (drug-induced kidney injury) | ||||||
Prescription medicines and peptides studied, for context
Angiotensin II
- Renal Recovery in AKI: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Renal Recovery in AKI Improvement | Improves (the measure goes up) | 2 studies |
Key findings
- Hyperphosphatemia Management in CKDImproves (the measure goes up)
- Acute Kidney Injury IncidenceImproves (the measure goes down)
- Plasma BCAA Levels in Renal InsufficiencyImproves (the measure goes up)
Safety notes in the studies
- This is an adverse effect warranting caution.
The Acute Kidney Injury Recovery Support protocol
2 primary supplements · 5 supporting supplements
- Vitamin E400–800 IU daily (mixed tocopherols)
- N-Acetyl Cysteine (NAC)600–1,200 mg twice daily (especially around contrast exposure)
Studies cited
17 studies from PubMed
- ANGIOTENSIN II FOR CATECHOLAMINE-RESISTANT VASODILATORY SHOCK IN PATIENTS WITH ACUTE KIDNEY INJURY: A POST HOC ANALYSIS OF THE ATHOS-3 TRIAL.
- Hyperphosphatemia
- Chaga mushroom-induced oxalate nephropathy that clinically manifested as nephrotic syndrome: A case report.
- Short-Term Effects of Branched-Chain Amino Acids-Enriched Dialysis Fluid on Branched-Chain Amino Acids Plasma Level and Mass Balance: A Randomized Cross-Over Study.
- Prediction of the mechanisms of action of Shenkang in chronic kidney disease: A network pharmacology study and experimental validation
- Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II.
- Branched Chain Amino Acids: Beyond Nutrition Metabolism.
- Tanshinone IIA Attenuates Contrast-Induced Nephropathy via Nrf2 Activation in Rats
- Branched-Chain Amino Acids and Brain Metabolism.
- Very low protein diets supplemented with keto-analogues in ESRD predialysis patients and its effect on vascular stiffness and AVF Maturation
- Improving diet recipe and cooking methods attenuates hyperphosphatemia in patients undergoing peritoneal dialysis
- Phosphate control in peritoneal dialysis
- Effect of ethanol extract of Sphaeranthus indicus on cisplatin-induced nephrotoxicity in rats
- Application of branched-chain amino acids in human pathological states: renal failure.
- Effect of a keto acid-amino acid supplement on the metabolism and renal elimination of branched-chain amino acids in patients with chronic renal insufficiency on a low protein diet.
- Secondary hyperparathyroidism in severe chronic renal failure is corrected by very-low dietary phosphate intake and calcium carbonate supplementation
- Renal protective effects of vitamin E for drug-induced kidney injury: a meta-analysis.