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Condition

Celiac Disease

Celiac disease is an autoimmune condition in which gluten, a protein in wheat, barley, and rye, turns the immune system against the small intestine's lining, impairing nutrient absorption. Evidence is strongest for iron and vitamin D, since the injured gut absorbs both poorly, and anemia was found in roughly 10 to 40 percent of people at diagnosis. Still, a strict gluten-free diet remains the only established approach, and evidence is limited for omega-3s.

Supplements studied
2
Graded outcomes
1
Trials
1
People studied
60

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

2 supplements

Gluten: outcomes studied for Celiac Disease
GradeOutcomeEffectSizeStudiesPeopleStudies list
Intestinal Damage

Gluten causes villous atrophy and malabsorption in celiac disease. Gluten-free diet is the ONLY treatment.

Changes; see studiesLarge effect10,000 people
L-Carnitine: outcomes studied for Celiac Disease
GradeOutcomeEffectSizeStudiesPeopleStudies list
Fatigue SymptomsImproves (the measure goes down)60 people

Key findings

  • Intestinal DamageGlutenChanges; see studies

The Celiac Disease Nutritional Support protocol

2 primary supplements · 8 supporting supplements

  • Vitamin D2,000–5,000 IU daily (often need higher doses; monitor levels)
  • IronAs directed based on ferritin levels (often need IV iron if oral not tolerated)

See the full protocol

Shop the evidence-backed picks

Support alongside medical care. These supplements are not a treatment for Celiac Disease. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.

Fullscript collectionGut and digestion: evidence-graded picksOpen on Fullscript

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Studies cited

None of the studies we hold is linked to the Celiac Disease outcomes on this page yet, so none is listed here. Each supplement’s page lists the studies on file for it.