Condition
Chronic Progressive External Ophthalmoplegia (CPEO)
Chronic progressive external ophthalmoplegia, or CPEO, is a mitochondrial disease in which the cells' energy machinery works poorly, slowly weakening the muscles that lift the eyelids and move the eyes. Coenzyme Q10 and L-carnitine are the supplements most often discussed for it, though little research on them in CPEO has been reviewed here so far. Because no trial findings are available to report, it's hard to say how well any supplement works for this condition.
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 1
- People studied
- 15
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Creatinine | Improves (the measure goes up) | 3 studies | 15 people | |||
Studies that measured creatinine
| ||||||
The Chronic Progressive External Ophthalmoplegia (CPEO) Supportive Care protocol
2 primary supplements · 7 supporting supplements
- Coenzyme Q10300–600 mg daily (ubiquinol form preferred for absorption)
- L-Carnitine2–3 g daily in divided doses
Studies cited
3 studies from PubMed
- Effects of long-term creatine supplementation on liver and kidney functions in American college football players
- Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebo-controlled, double-blind 31P-MRS crossover study
- Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans