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Condition

Diabetic Microangiopathy

Diabetic microangiopathy is damage to the body's smallest blood vessels caused by diabetes, and it underlies diabetic eye and kidney disease while contributing to nerve damage. Among supplements, the evidence is moderate for gotu kola, where trials found blood flow went up, and limited for curcumin, where one study found the same. Both studies were small, with about 100 and 25 people, so the picture is still early.

Sources: PMID 27630772

Supplements studied
2
Graded outcomes
2
Trials
3
People studied
125

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

2 supplements

Gotu Kola

Gotu Kola: outcomes studied for Diabetic Microangiopathy
GradeOutcomeEffectSizeStudiesPeopleStudies list
Blood Flow

Small Increase

Improves (the measure goes up)Small effect100 people
Leg EdemaChanges; see studies4 studies100 people

Studies that measured leg edema

and 1 more on the Gotu Kola page

MicrocirculationImproves (the measure goes up)3 studies100 people

Studies that measured microcirculation

Curcumin

Curcumin: outcomes studied for Diabetic Microangiopathy
GradeOutcomeEffectSizeStudiesPeopleStudies list
Blood Flow

Small Increase

Improves (the measure goes up)Small effect1 study25 people

Studies that measured blood flow

Leg EdemaChanges; see studies1 study25 people

Studies that measured leg edema

Key findings

  • Blood FlowGotu KolaImproves (the measure goes up)

The Diabetic Microangiopathy Supportive Care protocol

2 primary supplements · 5 supporting supplements

See the full protocol

Shop the evidence-backed picks

Support alongside medical care. These supplements are not a treatment for Diabetic Microangiopathy. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.

Fullscript collectionMetabolic health: evidence-graded picksOpen on Fullscript

Or shop one supplement

The supplement graded A or B for Diabetic Microangiopathy. Each opens the products we list for that supplement.

  • Grade B

We earn from purchases made in our Fullscript store, and links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Full disclosure

Studies cited

9 studies from PubMed

  1. Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled StudyJ Nutr Metab, 2016 · PMID 27630772
  2. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory modelAngiology · PMID 11666124
  3. Treatment of diabetic microangiopathy and edema with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled randomized studyAngiology · PMID 11666119
  4. Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trialAngiology · PMID 11666125
  5. Centella asiatica extract in venous disorders of the lower limbs. Comparative clinico-instrumental studies with a placeboClin Ter · PMID 7037273
  6. Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetryAngiology · PMID 11666123
  7. Flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiaticaAngiology · PMID 11666121
  8. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbsAngiology · PMID 3544968
  9. Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot studyPanminerva Med · PMID 22108476

Supplement stack for Diabetic Microangiopathy