Condition

Gout

Gout is a form of inflammatory arthritis in which high blood uric acid forms crystals in joints, causing sudden, severe pain, swelling, and redness. Vitamin C and tart cherry have the most support, with moderate evidence, yet a trial of tart cherry in 50 people found no clear difference in gout symptoms. That was a single small study, so the picture is still unsettled.

Sources: PMID 31891407

Supplements studied: 3
Graded outcomes: 2
Trials: 2
People studied: 14,731

Evidence by supplement

Strong
Moderate
Limited
Very limited

3 supplements

Tart Cherry Juice

Tart Cherry Juice: outcomes studied for Gout
Grade	Outcome	Effect	Size	Studies	People
	Gout Symptoms No effect		NoneNo effect	1 study	50 people
Studies that measured gout symptoms Lack of effect of tart cherry concentrate dose on serum urate in people with goutRheumatology · PMID 31891407
	HbA1c No effect		NoneNo effect		50 people
	Uric Acid	Improves (the measure goes down)		2 studies	50 people
Studies that measured uric acid Consumption of 100% Tart Cherry Juice Reduces Serum Urate in Overweight and Obese AdultsCurr Dev Nutr · PMID 31037275 Thirty Days of Montmorency Tart Cherry Supplementation Has No Effect on Gut Microbiome Composition, Inflammation, or Glycemic Control in Healthy AdultsFront Nutr · PMID 34604282

Fish Oil

Fish Oil: outcomes studied for Gout
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Gout Symptoms	Improves (the measure goes down)		1 study	40 people
Studies that measured gout symptoms Effect of omega-three supplementation on serum urate and gout flares in people with gout; a pilot randomized trial.BMC Rheumatol · PMID 35672866

Vitamin C

Vitamin C: outcomes studied for Gout
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Gout Symptoms	Improves (the measure goes down)		1 study	14,641 people
Studies that measured gout symptoms Effects of vitamin C supplementation on gout risk: results from the physicians' health study II trialAm J Clin Nutr · PMID 35575611

Key findings

Gout SymptomsTart Cherry Juice
HbA1cTart Cherry Juice

The Gout Support protocol

2 primary supplements · 3 supporting supplements

Vitamin C500–1,500 mg daily
Tart Cherry8–16 oz tart cherry juice or 480 mg cherry extract daily

See the full protocol

Shop the evidence-backed picks

Support alongside medical care. These supplements are not a treatment for Gout. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.

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Studies cited

5 studies from PubMed

Effects of vitamin C supplementation on gout risk: results from the physicians' health study II trialAm J Clin Nutr · PMID 35575611
Thirty Days of Montmorency Tart Cherry Supplementation Has No Effect on Gut Microbiome Composition, Inflammation, or Glycemic Control in Healthy AdultsFront Nutr · PMID 34604282
Lack of effect of tart cherry concentrate dose on serum urate in people with goutRheumatology · PMID 31891407
Consumption of 100% Tart Cherry Juice Reduces Serum Urate in Overweight and Obese AdultsCurr Dev Nutr · PMID 31037275
Effect of omega-three supplementation on serum urate and gout flares in people with gout; a pilot randomized trial.BMC Rheumatol · PMID 35672866