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Condition

Hemophilia

Hemophilia is an inherited bleeding disorder in which too little of a clotting protein, factor VIII or factor IX, means bleeding lasts longer, often into joints and muscles. Desmopressin has the strongest evidence, and studies found it raised factor VIII activity two- to four-fold, enough for minor surgery in mild hemophilia A without factor concentrates. Those findings concern mild hemophilia A; vitamin D and calcium for bone health have only moderate evidence.

Sources: PMID 15227644

Supplements studied
0
Medicines and peptides
1
Graded outcomes
2
No supplement studies yetWe haven’t found supplement studies for Hemophilia. The medicines and peptides studied for it are listed below.

Prescription medicines and peptides studied, for context

These are not supplements. Most need a prescription, and some are research compounds with no approved use.

1 medicine or peptide

Desmopressin (DDAVP)

Desmopressin (DDAVP): outcomes studied for Hemophilia
GradeOutcomeEffectSizeStudiesPeopleStudies list
von Willebrand Factor Levels

Up to 4-fold increase in vWF levels. Effective for von Willebrand disease Type I and some Type II variants.

Improves (the measure goes up)Large effect25 studies

Studies that measured von willebrand factor levels

and 22 more on the Desmopressin (DDAVP) page

Factor VIII Levels

2-4 fold increase in factor VIII coagulant activity, allowing minor surgery in mild hemophilia A without factor concentrates.

Improves (the measure goes up)Large effect21 studies

Studies that measured factor viii levels

and 18 more on the Desmopressin (DDAVP) page

Key findings

  • von Willebrand Factor LevelsDesmopressin (DDAVP)Improves (the measure goes up)
  • Factor VIII LevelsDesmopressin (DDAVP)Improves (the measure goes up)

The Hemophilia Supportive Care protocol

2 primary supplements · 7 supporting supplements

  • Vitamin D2,000–4,000 IU daily (monitor levels; target >40 ng/mL)
  • Calcium1,000–1,200 mg daily (from diet + supplements)

See the full protocol

Studies cited

25 studies from PubMed

  1. A Review of Desmopressin Use in Bleeding Disorders: An Unsung Hero?Biomolecules, 2025 · PMID 40723839
  2. Desmopressin (DDAVP) use in patients with von Willebrand disease: A single-centre retrospective review of test response and clinical outcomes.Haemophilia : the official journal of the World Federation of Hemophilia, 2023 · PMID 37257847
  3. Desmopressin to Prevent Rapid Sodium Correction in Severe Hyponatremia: A Systematic Review.The American journal of medicine, 2015 · PMID 26031887
  4. The use of desmopressin in acquired haemophilia A: a systematic review.Blood transfusion = Trasfusione del sangue, 2011 · PMID 21839010
  5. Adenotonsillectomy in patients with desmopressin responsive mild bleeding disorders: a review of the literature.Haemophilia : the official journal of the World Federation of Hemophilia, 2010 · PMID 20028423
  6. The use of desmopressin as a hemostatic agent: a concise review.American journal of hematology, 2007 · PMID 17492648
  7. Vasopressin and desmopressin in central diabetes insipidus: adverse effects and clinical considerationsPituitary, 2006 · PMID 16456490
  8. The risk of hyponatremia in older adults using desmopressin for nocturia: a systematic review and meta-analysis.Neurourology and urodynamics, 2004 · PMID 15227644
  9. Intranasal desmopressin-associated hyponatremia: a case report and literature review.The Journal of family practice, 1997 · PMID 9040524
  10. Desmopressin for diabetes insipidus, hemostatic disorders and enuresisSchweiz Rundsch Med Prax, 1990 · PMID 2220513
  11. DesmopressinAnn Intern Med, 1985 · PMID 3893256
  12. Effectiveness of meditation for fatigue management: Insight from a comprehensive systematic review and meta-analysis.Gen Hosp Psychiatry · PMID 39244428
  13. Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trialPLoS One · PMID 25268730
  14. Rhodiola rosea (SHR-5), Part I: a proprietary root extract of Rhodiola rosea is found to be effective in the treatment of stress-related fatigueHolist Nurs Pract · PMID 24503750
  15. The influence of adaptogens on ultraweak biophoton emission: a pilot-experimentPhytother Res · PMID 19170145
  16. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatiguePlanta Med · PMID 19016404
  17. Safety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trialJ Ginseng Res · PMID 31695571
  18. Anti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled TrialJ Altern Complement Med · PMID 27754709
  19. L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolismNutr Res · PMID 19083482
  20. A randomized, double-masked, placebo-controlled crossover trial on the effects of L-ornithine on salivary cortisol and feelings of fatigue of flushers the morning after alcohol consumptionBiopsychosoc Med · PMID 23414576
  21. Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trialCMAJ · PMID 22777991
  22. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigueArch Gerontol Geriatr · PMID 17658628
  23. Effects of Acute Guarana (Paullinia cupana) Ingestion on Mental Performance and Vagal Modulation Compared to a Low Dose of Caffeine.Nutrients · PMID 38931247
  24. Effects of branched-chain amino acids supplementation on physiological and psychological performance during an offshore sailing raceEur J Appl Physiol · PMID 18704484
  25. The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind randomized studyJ Int Soc Sports Nutr · PMID 18992136