Condition
Nocturnal Enuresis
Nocturnal enuresis is bedwetting during sleep, which happens when a child's body makes a lot of urine overnight, the bladder holds little, or sleep is too deep to notice a full bladder. Among options studied, the evidence is strongest for desmopressin, and trials found about 2.2 fewer wet nights per week than placebo. Still, only about 35% of children became completely dry, and a review also described cases of severe low blood sodium.
Sources: PMID 2220513; PMID 23619353
- Updated
- How we grade
- 25 studies cited
- Supplements studied
- 0
- Medicines and peptides
- 1
- Graded outcomes
- 2
No supplement studies yetWe haven’t found supplement studies for Nocturnal Enuresis. The medicines and peptides studied for it are listed below.
Prescription medicines and peptides studied, for context
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Wet Nights (Enuresis) 2.2 fewer wet nights per week vs placebo. Children 4.5x more likely to sleep without disruption. 35% achieved complete dryness in studies. | Improves (the measure goes down) | Large effect | 25 studies | |||
Studies that measured wet nights (enuresis) | ||||||
| Sleep Quality (Enuresis) Improved sleep quality and reduced sleep disruption in children and adults with nocturnal enuresis. | Improves (the measure goes up) | Moderate effect | 25 studies | |||
Studies that measured sleep quality (enuresis) | ||||||
Key findings
- Wet Nights (Enuresis)Improves (the measure goes down)
- Sleep Quality (Enuresis)Improves (the measure goes up)
Studies cited
25 studies from PubMed
- A Review of Desmopressin Use in Bleeding Disorders: An Unsung Hero?
- Desmopressin to Prevent Rapid Sodium Correction in Severe Hyponatremia: A Systematic Review.
- Severe signs of hyponatremia secondary to desmopressin treatment for enuresis: a systematic review.
- The use of desmopressin in acquired haemophilia A: a systematic review.
- Adenotonsillectomy in patients with desmopressin responsive mild bleeding disorders: a review of the literature.
- The use of desmopressin as a hemostatic agent: a concise review.
- Vasopressin and desmopressin in central diabetes insipidus: adverse effects and clinical considerations
- The risk of hyponatremia in older adults using desmopressin for nocturia: a systematic review and meta-analysis.
- Intranasal desmopressin-associated hyponatremia: a case report and literature review.
- Desmopressin for diabetes insipidus, hemostatic disorders and enuresis
- Desmopressin
- Effectiveness of meditation for fatigue management: Insight from a comprehensive systematic review and meta-analysis.
- Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial
- Rhodiola rosea (SHR-5), Part I: a proprietary root extract of Rhodiola rosea is found to be effective in the treatment of stress-related fatigue
- The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment
- A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue
- Safety and antifatigue effect of Korean Red Ginseng: a randomized, double-blind, and placebo-controlled clinical trial
- Anti-Fatigue Effects of Enzyme-Modified Ginseng Extract: A Randomized, Double-Blind, Placebo-Controlled Trial
- L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism
- A randomized, double-masked, placebo-controlled crossover trial on the effects of L-ornithine on salivary cortisol and feelings of fatigue of flushers the morning after alcohol consumption
- Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial
- Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue
- Effects of Acute Guarana (Paullinia cupana) Ingestion on Mental Performance and Vagal Modulation Compared to a Low Dose of Caffeine.
- Effects of branched-chain amino acids supplementation on physiological and psychological performance during an offshore sailing race
- The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind randomized study