Condition
Hypogonadotropic Hypogonadism
Hypogonadotropic hypogonadism is a condition in which the pituitary gland releases too little LH and FSH, so the testes or ovaries make too little sex hormone. Research has focused on gonadorelin, a diagnostic test rather than a supplement, and the evidence is strong that it shows how the pituitary responds by measuring LH and FSH. Before puberty it could not separate this condition from constitutionally delayed puberty, but afterward it was useful.
Sources: PMID 15554892
- Updated
- How we grade
- 82 studies cited
- Supplements studied
- 0
- Medicines and peptides
- 1
- Graded outcomes
- 4
No supplement studies yetWe haven’t found supplement studies for Hypogonadotropic Hypogonadism. The medicines and peptides studied for it are listed below.
Prescription medicines and peptides studied, for context
Key findings
- Puberty InductionImproves (the measure goes up)
- Diagnostic AccuracyImproves (the measure goes up)
- Spermatogenesis InductionImproves (the measure goes up)
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Support alongside medical care. These supplements are not a treatment for Hypogonadotropic Hypogonadism. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
82 studies from PubMed
- Gonadotropin Treatment for the Male Hypogonadotropic Hypogonadism
- Role of Gonadotropin-releasing Hormone Stimulation Test in Diagnosing Gonadotropin Deficiency in Both Males and Females with Delayed Puberty
- [Micropump infusion of gonadorelin in the treatment of hypogonadotropic hypogonadism in patients with pituitary stalk interruption syndrome: cases analysis and literature review].
- Application of gonadotropin releasing hormone in hypogonadotropic hypogonadism--diagnostic and therapeutic aspects
- Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training
- IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training
- Regular consumption of concord grape juice benefits human immunity
- The influence of resistance training on inflammatory markers, body composition and functional capacity in healthy older adults: A systematic review and meta-analysis.
- Effects of Dietary Patterns on Biomarkers of Inflammation and Immune Responses: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Effect of plant-based diets on obesity-related inflammatory profiles: a systematic review and meta-analysis of intervention trials
- Systemic production of IFN-alpha by garlic (Allium sativum) in humans
- Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer
- Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial
- Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects
- Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons
- Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers
- Daily supplementation of tocotrienol-rich fraction or alpha-tocopherol did not induce immunomodulatory changes in healthy human volunteers
- Vitamin D, tuberculin skin test conversion, and latent tuberculosis in Mongolian school-age children: a randomized, double-blind, placebo-controlled feasibility trial
- Winter cholecalciferol supplementation at 55°N has little effect on markers of innate immune defense in healthy children aged 4-8 years: a secondary analysis from a randomized controlled trial
- The clinical and biochemical effects of vitamin C supplementation in short-stay hospitalized geriatric patients
- The effects of ascorbic acid and flavonoids on the occurrence of symptoms normally associated with the common cold
- Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon
- Vitamin C supplementation and salivary immune function following exercise-heat stress
- The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man
- Effect of vitamin C supplementation on lipid peroxidation, muscle damage and inflammation after 30-min exercise at 75% VO2max
- Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers
- Immunomodulation in Middle-Aged Humans Via the Ingestion of Physta® Standardized Root Water Extract of Eurycoma longifolia Jack--A Randomized, Double-Blind, Placebo-Controlled, Parallel Study.
- L-Theanine reduces psychological and physiological stress responses
- Enhancement of natural killer cell activity in healthy subjects by Immulina®, a Spirulina extract enriched for Braun-type lipoproteins
- The effects of Spirulina on anemia and immune function in senior citizens
- Monocyte chemoattractant protein-1 polymorphism interaction with spirulina immunomodulatory effects in healthy Korean elderly: A 16 week, double-blind randomized clinical trial
- Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: a randomized double-blind placebo-controlled study
- Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial
- Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial
- Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo
- Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on "living high-training low"
- Ganoderma lucidum suppresses endothelial cell cytotoxicity and proteinuria in persistent proteinuric focal segmental glomerulosclerosis (FSGS) nephrosis
- Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trial
- Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer
- Thermotolerance and heat acclimation may share a common mechanism in humans
- Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease
- New developments in the treatment of COPD: comparing the effects of inhaled corticosteroids and N-acetylcysteine
- Daily probiotic's (Lactobacillus casei Shirota) reduction of infection incidence in athletes
- Iodine intakes of 100-300 μg/d do not modify thyroid function and have modest anti-inflammatory effects
- The effect of hesperidin supplementation on inflammatory markers in human adults: A systematic review and meta-analysis of randomized controlled clinical trials.
- Orange juice and its major polyphenol hesperidin consumption do not induce immunomodulation in healthy well-nourished humans
- Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
- Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans
- The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients
- Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young males
- The effects of eicosapentaenoic acid-fortified food on inflammatory markers in healthy subjects--A randomized, placebo-controlled, double-blind study
- Fish oil supplementation augments post-exercise immune function in young males
- Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers
- Supplementation with omega3 polyunsaturated fatty acids and all-rac alpha-tocopherol alone and in combination failed to exert an anti-inflammatory effect in human volunteers
- Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents
- The effect of low-dose marine n-3 fatty acids on the biosynthesis of pro-inflammatory 5-lipoxygenase pathway metabolites in overweight subjects: a randomized controlled trial
- Flow-cytometric studies with eleutherococcus senticosus extract as an immunomodulatory agent
- The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man
- Echinacea purpurea and mucosal immunity
- Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men
- Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans
- A high intake of trans fatty acids has little effect on markers of inflammation and oxidative stress in humans
- Conjugated linoleic acid increased C-reactive protein in human subjects
- Lack of prophylactic efficacy of an enteric-coated bovine hyperimmune milk product against enterotoxigenic Escherichia coli challenge administered during a standard meal
- A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans
- Effect of a mixture of micronutrients, but not of bovine colostrum concentrate, on immune function parameters in healthy volunteers: a randomized placebo-controlled study
- Modulation of human humoral immune response through orally administered bovine colostrum
- Effect of bovine colostrum supplementation on respiratory tract mucosal defenses in swimmers
- The effect of bovine colostrum supplementation on salivary IgA in distance runners
- Mediterranean Diet Supplemented With Coenzyme Q10 Modifies the Expression of Proinflammatory and Endoplasmic Reticulum Stress-Related Genes in Elderly Men and Women
- Salivary secretory immunoglobulin A secretion increases after 4-weeks ingestion of chlorella-derived multicomponent supplement in humans: a randomized cross over study
- Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial
- Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa
- Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults
- Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines
- The adjuvant use of calcium fructoborate and borax with etanercept in patients with rheumatoid arthritis: Pilot study
- The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study
- Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans
- Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players
- Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial
- In vivo effects of Ashwagandha (Withania somnifera) extract on the activation of lymphocytes
- Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y