Peptide
Gonadorelin (Factrel)
Gonadorelin is a synthetic decapeptide identical to endogenous GnRH. FDA-approved as diagnostic agent for evaluating pituitary gonadotrope function. Also used therapeutically for hypogonadotropic hypogonadism via pulsatile pump. In males with HH, pulsatile GnRH achieves spermatogenesis in 85% (58/68 patients). Earlier spermatogenesis vs gonadotropin therapy (6 vs 14 months, p=0.01).
- Updated
- How we grade
- 27 studies cited
Research notice. This page is for education and research. Peptides may not be FDA-approved for human use and may only be legally available for research. Talk to a qualified clinician before considering any peptide.
- Best evidence
- Grade A
- Conditions studied
- 1
- Outcomes
- 10
- Graded outcomes
- 4051
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
General
Key findings
- Puberty InductionImproves (the measure goes up)
- Diagnostic AccuracyImproves (the measure goes up)
- Spermatogenesis InductionImproves (the measure goes up)
Studies cited
27 studies from PubMed
- Effects of gonadorelin on gonadotropin expression, plasma sex steroid concentrations and ovarian follicle dynamics in mature tambaqui (Colossoma macropomum).
- A biomimetic enzyme-linked immunosorbent assay (BELISA) for the analysis of gonadorelin by using molecularly imprinted polymer-coated microplates.
- The safety of neoadjuvant hormonal treatment in infants with cryptorchidism.
- Gonadotropin Treatment for the Male Hypogonadotropic Hypogonadism
- Impact of phase of the estrous cycle and season on LH surge profile and fertility in dairy cows treated with different GnRH analogs (gonadorelin vs. buserelin).
- Role of Gonadotropin-releasing Hormone Stimulation Test in Diagnosing Gonadotropin Deficiency in Both Males and Females with Delayed Puberty
- Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle.
- Effect of different gonadorelin (GnRH) products used for the first or resynchronized timed artificial insemination on pregnancy rates in postpartum dairy cows.
- Raloxifene and antiestrogenic gonadorelin inhibits intestinal tumorigenesis by modulating immune cells and decreasing stem-like cells.
- [Micropump infusion of gonadorelin in the treatment of hypogonadotropic hypogonadism in patients with pituitary stalk interruption syndrome: cases analysis and literature review].
- Comparison of gonadorelin products in lactating dairy cows: efficacy based on induction of ovulation of an accessory follicle and circulating luteinizing hormone profiles.
- [Side effects of treatment with the long-acting gonadorelin agonist triptorelin in a case of paraphilia].
- [Ovulation inducing drugs].
- The effect of different doses of gonadorelin on ovarian follicle dynamics in river buffalo (Bubalus bubalis).
- The effects of 3 gonadorelin products on luteinizing hormone release, ovulation, and follicular wave emergence in cattle.
- If gonadotropin-releasing hormone plus growth hormone (GH) really improves growth outcomes in short non-GH-deficient children, then what?
- [Research progress in immune regulation of gonadorelin].
- Gonadorelin-induced testosterone release: a biological assay for quality assurance of gonadorelin in veterinary medicine.
- Response to gonadotrophin-releasing hormone by the intact male dog: serum testosterone, luteinizing hormone and follicle-stimulating hormone.
- GnRH analogues in reproductive medicine.
- Gonadorelin for induction of ovulation.
- [Treatment of cancer of the prostate. Role of gonadorelin analogs].
- Immunoglobulin-mediated hypersensitivity in response to long-term treatment with gonadorelin hydrochloride (Factrel) in a female patient.
- Application of gonadotropin releasing hormone in hypogonadotropic hypogonadism--diagnostic and therapeutic aspects
- Ovulation induction with pulsatile intravenous GnRH.
- [Treatment of advanced prostatic cancer with a gonadorelin agonist, dTrp6 LHRH. 41 cases].
- The International Reference Preparation of Gonadorelin for Bioassay: a comparison with different preparations of synthetic luteinizing hormone releasing hormone using physicochemical methods of analysis, different bioassays and immunoassay.