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Condition

Intrahepatic Cholestasis of Pregnancy (ICP)

Intrahepatic cholestasis of pregnancy is a liver condition of the third trimester in which bile acids build up in the blood, causing intense itching, especially on the palms and soles, and it clears up after delivery. Little research on supplements for it has been reviewed here so far, so there are no trial findings to report yet. Vitamins K, D and E are discussed because cholestasis can interfere with absorbing fat-soluble vitamins, but that is a rationale rather than a result.

Supplements studied
1
Graded outcomes
0
Trials
1
People studied
2,085

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

1 supplement

S-adenosylmethionine

S-adenosylmethionine: outcomes studied for Intrahepatic Cholestasis of Pregnancy (ICP)
GradeOutcomeEffectSizeStudiesPeopleStudies list
CholestasisChanges; see studies2 studies2,085 people

Studies that measured cholestasis

The Intrahepatic Cholestasis of Pregnancy Supportive Care protocol

2 primary supplements · 4 supporting supplements

  • S-Adenosylmethionine (SAMe)800–1,600 mg daily in divided doses
  • Ursodeoxycholic Acid (UDCA)10–15 mg/kg/day (prescription medication)

See the full protocol

Studies cited

2 studies from PubMed

  1. Pharmacological interventions for treating intrahepatic cholestasis of pregnancy.Cochrane Database Syst Rev · PMID 32716060
  2. Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancyJ Perinat Med · PMID 16965225

Supplement stack for Intrahepatic Cholestasis of Pregnancy (ICP)