Condition
Ligament Injury
A ligament injury is a sprain or tear of the tough bands that hold bones together at a joint, such as the knee or ankle, and recovery can take weeks to months. The only research on it here concerns TB-500, a lab-made fragment of the peptide thymosin beta-4, which helped injured knee ligaments repair in rats. That work is almost all animal and lab research, so it is not known whether the same happens in people.
Sources: PMID 23523891
- Updated
- How we grade
- 4 studies cited
- Supplements studied
- 0
- Medicines and peptides
- 1
- Graded outcomes
- 1
Prescription medicines and peptides studied, for context
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Ligament/Tendon Healing Enhanced healing of medial collateral ligament injury in animal models. Promotes organized connective tissue formation and reduces myofibroblast appearance. | Improves (the measure goes up) | Moderate effect | 4 studies | 45 people | ||
Key findings
- Ligament/Tendon HealingImproves (the measure goes up)
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Studies cited
4 studies from PubMed
- Thymosin β(4) and β(10) Expression in Human Organs during Development: A Review.
- Thymosin β4 enhances the healing of medial collateral ligament injury in rat
- Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications
- Thymosin beta4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts