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Neurodegeneration

Neurodegeneration is the gradual loss of nerve cells and their connections in the brain and spinal cord, as seen in conditions like Alzheimer's disease. Among supplements, TB-500, a peptide related to thymosin beta-4, has drawn attention, and preclinical studies found it lessened neuronal damage and helped neural stem cells migrate. The evidence is very limited, though, because the work was small and mostly in animals or lab studies.

Sources: PMID 22074294; PMID 36709593

Supplements studied
0
Medicines and peptides
1
Graded outcomes
1
No supplement studies yetWe haven’t found supplement studies for Neurodegeneration. The medicines and peptides studied for it are listed below.

Prescription medicines and peptides studied, for context

These are not supplements. Most need a prescription, and some are research compounds with no approved use.

1 medicine or peptide

TB-500

TB-500: outcomes studied for Neurodegeneration
GradeOutcomeEffectSizeStudiesPeopleStudies list
Neuroprotection

Attenuates neuronal damage in preclinical models. Potential Alzheimer's intervention target - TMSB4X expression decreased in AD neurons. Promotes neural stem cell migration.

Improves (the measure goes up)Small effect5 studies50 people

Studies that measured neuroprotection

and 2 more on the TB-500 page

Key findings

  • NeuroprotectionTB-500Improves (the measure goes up)

Shop the evidence-backed picks

Support alongside medical care. These supplements are not a treatment for Neurodegeneration. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.

Fullscript collectionFocus and memory: evidence-graded picksOpen on Fullscript

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Studies cited

5 studies from PubMed

  1. Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoidsStem Cell Reports, 2025 · PMID 40816274
  2. Thymosin β(4) and β(10) Expression in Human Organs during Development: A Review.Cells, 2024 · PMID 38994967
  3. Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapiesInt Immunopharmacol, 2023 · PMID 36709593
  4. Thymosin beta-4 prenatal administration improves fetal development and halts side effects due to preterm deliveryEur Rev Med Pharmacol Sci, 2021 · PMID 33506933
  5. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applicationsAnn N Y Acad Sci, 2012 · PMID 22074294