Condition
Liver Cancer
Hepatocellular carcinoma is the most common primary liver cancer, usually starting in a liver already damaged by long-term disease such as hepatitis or cirrhosis. Among supplements, vitamin K has the clearest research, and studies found cancer deaths were lower, with the evidence rated moderate. Those studies were small, and they looked at cancer mortality only, so they say little about other outcomes.
- Supplements studied
- 2
- Graded outcomes
- 1
- Trials
- 3
- People studied
- 2,155
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cancer Mortality Small Improvement | Improves (the measure goes down) | Small effect | 1,980 people | |||
| Liver Cancer Risk | Changes; see studies | 3 studies | 1,980 people | |||
Studies that measured liver cancer risk
| ||||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cancer Metastasis | Improves (the measure goes up) | 1 study | 13 people | |||
Key findings
- Cancer MortalityImproves (the measure goes down)
The Liver Cancer (Hepatocellular Carcinoma) Supportive Care protocol
2 primary supplements · 6 supporting supplements
- Vitamin D2,000–4,000 IU daily (may need higher doses in cirrhosis; monitor levels)
- Omega-3 Fatty Acids2–3 g EPA+DHA daily
Studies cited
4 studies from PubMed
- The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study
- Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controlled trial
- The Efficacy of Vitamin K, A Member Of Naphthoquinones in the Treatment of Cancer: A Systematic Review and Meta-Analysis
- Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial