Condition
Microangiopathy
Microangiopathy is disease of the body's smallest blood vessels, most often in diabetes, where long-term high blood sugar, oxidative stress and inflammation damage vessel walls and reduce blood flow to the eyes, kidneys and nerves. Among supplements, a ginkgo study found better microcirculation, and gotu kola research found blood flow went up. The evidence for both is limited, though: the ginkgo study involved just 32 elderly patients, and the gotu kola work was small too.
Sources: PMID 22120894
- Supplements studied
- 2
- Graded outcomes
- 2
- Trials
- 3
- People studied
- 171
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Microcirculation Small Improvement | Improves (the measure goes up) | Small effect | 1 study | 32 people | ||
Studies that measured microcirculation | ||||||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 32 people | ||||
Key findings
- MicrocirculationImproves (the measure goes up)
- Blood FlowImproves (the measure goes up)
The Microangiopathy (Small Vessel Disease) Supportive Care protocol
2 primary supplements · 6 supporting supplements
- Alpha-Lipoic Acid600–1,200 mg daily in divided doses
- Vitamin B1 (Benfotiamine)150–300 mg benfotiamine daily
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Microangiopathy. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
Fullscript collectionHeart and circulation: evidence-graded picksOpen on Fullscript
The collection holds the supplements we grade A or B for its theme, in products from the Fullscript catalog. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
We earn from purchases made in our Fullscript store, and links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Full disclosure
Studies cited
89 studies from PubMed
- Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGb 761) in healthy volunteers
- Effect of Ginkgo biloba (EGb 761) on treadmill walking time among adults with peripheral artery disease: a randomized clinical trial
- Study of the antiischemic action of EGb 761 in the treatment of peripheral arterial occlusive disease by TcPo2 determination
- 6-Month double-blind randomised clinical trial of Ginkgo biloba extract versus placebo in two parallel groups in patients suffering from peripheral arterial insufficiency
- Reduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (EGb 761) in cardiovascular high-risk patients
- Does Ginkgo biloba reduce the risk of cardiovascular events
- A new ginkgo fresh plant extract increases microcirculation and radical scavenging activity in elderly patients
- Ginkgo biloba for attention-deficit/hyperactivity disorder in children and adolescents: a double blind, randomized controlled trial
- Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine
- Ginkgo biloba for antidepressant-induced sexual dysfunction
- A placebo-controlled study of extract of ginkgo biloba added to clozapine in patients with treatment-resistant schizophrenia
- The effect of extract of ginkgo biloba addition to olanzapine on therapeutic effect and antioxidant enzyme levels in patients with schizophrenia
- A double-blind, placebo-controlled trial of extract of Ginkgo biloba added to haloperidol in treatment-resistant patients with schizophrenia
- Brain-derived neurotrophic factor levels and its Val66Met gene polymorphism predict tardive dyskinesia treatment response to Ginkgo biloba
- Phase II study of Ginkgo biloba in irradiated brain tumor patients: effect on cognitive function, quality of life, and mood
- Triple-blind, placebo-controlled trial of Ginkgo biloba in sexual dysfunction due to antidepressant drugs
- Short- and long-term effects of Ginkgo biloba extract on sexual dysfunction in women
- An examination of the efficacy of Ginkgo biloba extract EGb761 on the neuropsychologic functioning of cognitively intact older adults
- Acute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserine
- A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings
- Cognitive performance, SPECT, and blood viscosity in elderly non-demented people using Ginkgo biloba
- Ginkgo biloba extract EGb 761(R), donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: a randomised, double-blind, exploratory trial
- Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761® in Alzheimer's disease and vascular dementia: results from a randomised controlled trial
- Effects of Ginkgo biloba on cerebral blood flow assessed by quantitative MR perfusion imaging: a pilot study
- Ginkgo biloba special extract in dementia with neuropsychiatric features. A randomised, placebo-controlled, double-blind clinical trial
- Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia
- Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg
- Effect of Western medicine therapy assisted by Ginkgo biloba tablet on vascular cognitive impairment of none dementia
- A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group.
- Ginkgo biloba for prevention of dementia: a randomized controlled trial
- Ginkgo biloba for the prevention of severe acute mountain sickness (AMS) starting one day before rapid ascent
- Randomised, double blind, placebo controlled comparison of ginkgo biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high altitude illness trial (PHAIT)
- Ginkgo biloba does--and does not--prevent acute mountain sickness
- Ginkgo biloba decreases acute mountain sickness in people ascending to high altitude at Ollagüe (3696 m) in northern Chile
- Ginkgo biloba and acetazolamide prophylaxis for acute mountain sickness: a randomized, placebo-controlled trial
- EGb 761 in control of acute mountain sickness and vascular reactivity to cold exposure
- Clonazepam quiets tinnitus: a randomised crossover study with Ginkgo biloba
- Ginkgo biloba for tinnitus
- Effectiveness of Ginkgo biloba in treating tinnitus: double blind, placebo controlled trial
- Effect of Ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy
- The effect of Li 1370, extract of Ginkgo biloba, on REM sleep in humans
- Ginkgo biloba for acute ischaemic stroke
- Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial
- Value of standardized Ginkgo biloba extract (EGb 761) in the management of congestive symptoms of premenstrual syndrome
- Influence of Ginkgo biloba on ocular blood flow
- Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma
- Ginkgo biloba extract increases ocular blood flow velocity
- A randomized, placebo-controlled trial of Ginkgo biloba L. in treatment of premenstrual syndrome
- Specific memory effects of Ginkgo biloba extract EGb 761 in middle-aged healthy volunteers
- Effects of a Ginkgo biloba extract on forearm haemodynamics in healthy volunteers
- Effect of Ginkgo biloba on blood pressure and incidence of hypertension in elderly men and women
- Acute effects of Ginkgo biloba extract on vascular function and blood pressure
- Treatment of age-related memory complaints with Ginkgo biloba extract: a randomized double blind placebo-controlled study
- Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial
- Safety and effectiveness of a traditional ginkgo fresh plant extract - results from a clinical trial
- Ginkgo biloba and risk of cancer: secondary analysis of the Ginkgo Evaluation of Memory (GEM) Study
- Ginkgo biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials
- A clinical trial of Gingkco Biloba Extract in patients with intermittent claudication
- Demonstration of the efficacy of ginkgo biloba special extract EGb 761 on intermittent claudication--a placebo-controlled, double-blind multicenter trial
- Ginkgo biloba does not improve cognitive function in MS: a randomized placebo-controlled trial
- Clinical efficacy comparison of anti-wrinkle cosmetics containing herbal flavonoids
- Evidence of the regulatory effect of Ginkgo biloba extract on skin blood flow and study of its effects on urinary metabolites in healthy humans
- A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction
- No significant effect of ginkgo biloba special extract EGb 761 in the treatment of primary Raynaud phenomenon: a randomized controlled trial
- To compare the efficacy and safety of nifedipine sustained release with Ginkgo biloba extract to treat patients with primary Raynaud's phenomenon in South Korea; Korean Raynaud study (KOARA study)
- Effectiveness of oral Ginkgo biloba in treating limited, slowly spreading vitiligo
- Ginkgo biloba for the treatment of vitilgo vulgaris: an open label pilot clinical trial
- First preliminary results of an observation of Ginkgo Biloba treating patients with autistic disorder
- A double-blind placebo controlled trial of Ginkgo biloba added to risperidone in patients with autistic disorders
- Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: a randomized, double-blind, placebo-controlled trial
- Short-term effects of Ginkgo biloba extract on peripapillary retinal blood flow in normal tension glaucoma
- The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled trials.
- Efficacy of ginkgo biloba extract in the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis of randomized controlled trials.
- Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs
- Flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiatica
- Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry
- Centella asiatica extract in venous disorders of the lower limbs. Comparative clinico-instrumental studies with a placebo
- Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside
- The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study
- Improvement of capillary permeability in patients with venous hypertension after treatment with TTFCA
- Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica
- A clinical study on the management of generalized anxiety disorder with Centella asiatica
- Total triterpenic fraction of Centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model
- Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial
- Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: a clinical, prospective, placebo-controlled, randomized, dose-ranging trial
- Treatment of diabetic microangiopathy and edema with total triterpenic fraction of Centella asiatica: a prospective, placebo-controlled randomized study
- Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model
- The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients
- A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects