Condition

Pain

Pain is the nervous system's alarm, with nerves sending signals that the brain and spinal cord weigh and amplify, and chronic pain is when that alarm keeps sounding long after an injury should have settled. Among supplements, the one with findings so far is DSIP, a small peptide, and studies found chronic pain intensity went down. That rests on just four small studies with 35 people in total, so the evidence is limited.

Sources: PMID 6548970

Updated 7 November 2026
How we grade
4 studies cited

Supplements studied: 0
Medicines and peptides: 1
Graded outcomes: 1

No supplement studies yetWe haven’t found supplement studies for Pain. The medicines and peptides studied for it are listed below.

Prescription medicines and peptides studied, for context

These are not supplements. Most need a prescription, and some are research compounds with no approved use.

1 medicine or peptide

DSIP (Delta Sleep-Inducing Peptide)

DSIP (Delta Sleep-Inducing Peptide): outcomes studied for Pain
Grade	Outcome	Effect	Size	Studies	People	Studies list
	Chronic Pain Intensity Moderate Reduction	Improves (the measure goes down)	Moderate effect	4 studies	35 people
Studies that measured chronic pain intensity Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trialJ Clin Psychopharmacol · 1998 · PMID 9617990 A clinical trial with DSIPEur Neurol · 1984 · PMID 6391926 Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot studyEur Neurol · 1984 · PMID 6548970 and 1 more on the DSIP (Delta Sleep-Inducing Peptide) page

What the published studies found

1 automated reading

Automated reading of the published studies (Decosa evidence engine), for outcomes Winnowleaf has not graded yet. It is not a Winnowleaf grade and does not change one. How it is read

Ginger (Zingiber officinale): pain
A Cochrane review (2016, 27 studies, 3,101 people) found an improvement in pain. That review studied women with primary or secondary dysmenorrhoea. 7 of the 9 studies read agree; 2 found no clear answer. The evidence is limited.
Side effects: 1 of the 3 studies that reported on them found more with Ginger (Zingiber officinale) (withdrawals due to adverse events).
9 studies counted of 11 read: 9 reviews.
1. Meta-analysis, 2016; 27 studies, 3,101 people; women with primary or secondary dysmenorrhoea: improves (the review the verdict rests on). ginger (MD -1.55 points, 95% CI -2.43 to -0.68 Dietary supplements for dysmenorrhoeaPubMed 27000311
2. Meta-analysis, 2024; 12 studies; women with primary dysmenorrhea: improves. ginger is notably more effective than placebo in reducing both the intensity Ginger for Pain Management in Primary Dysmenorrhea: A Systematic Review and Meta-AnalysisPubMed 38770631
3. Meta-analysis, 2022; 3 studies, 330 people: improves. Pain was the only clinical parameter that significantly decreased A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis SymptomsPubMed 35458170
4. Meta-analysis, 2021; 3 studies: improves. reduced pain scores at 2 h (MD = -1.27 The efficacy of ginger for the treatment of migraine: A meta-analysis of randomized controlled studiesPubMed 33293189
5. Meta-analysis, 2020; 4 studies; patients with knee osteoarthritis: unclear: evidence too weak to tell. mean difference for pain was -7.88 mm Effectiveness of Ginger on Pain and Function in Knee Osteoarthritis: A PRISMA Systematic Review and Meta-AnalysisPubMed 32214292
6. Meta-analysis, 2019; 11 studies, 693 people; adults undergoing laparoscopic, obstetrical or cardiovascular surgeries: unclear: evidence too weak to tell. reduction in the need for rescue medication for pain Herbal medications for anxiety, depression, pain, nausea and vomiting related to preoperative surgical patients: a systematic review and meta-analysis of randomised controlled trialsPubMed 31129571
7. Meta-analysis, 2016; 6 studies; women with dysmenorrhea: improves. weighted mean difference on a 10 cm visual analogue scale was 1.55 cm Efficacy of Oral Ginger (Zingiber officinale) for Dysmenorrhea: A Systematic Review and Meta-AnalysisPubMed 27274753
8. Meta-analysis, 2015; 5 studies, 593 people; osteoarthritis patients aged over 18 years: improves. statistically significant pain reduction SMD = -0.30 Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trialsPubMed 25300574
9. Systematic review, 2015; 7 studies; athletes and untrained individuals: improves. modestly reduce muscle pain stemming from Ginger (Zingiber officinale) as an Analgesic and Ergogenic Aid in Sport: A Systemic ReviewPubMed 26200194
Automated reading of the published studies (Decosa evidence engine), run 30 Sep 2026. It reads abstracts, can miss studies, and a repeat run can differ.

Key findings

Chronic Pain IntensityDSIP (Delta Sleep-Inducing Peptide)Improves (the measure goes down)

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Studies cited

4 studies from PubMed

Opioid detoxification with delta sleep-inducing peptide: results of an open clinical trialJ Clin Psychopharmacol, 1998 · PMID 9617990
Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot studyEur Neurol, 1984 · PMID 6548970
A clinical trial with DSIPEur Neurol, 1984 · PMID 6391926
Use of probiotics in the treatment of functional abdominal pain in children-systematic review and meta-analysisEur J Pediatr · PMID 32940743