Condition
Pancreatitis
Pancreatitis is inflammation of the pancreas, the organ that makes digestive enzymes and insulin; in acute cases, those enzymes switch on inside the gland and digest it. The evidence is strongest for pancreatic enzymes and vitamin D, which address poor digestion and low fat-soluble vitamins, while secretin testing assessed pancreatic function with roughly 79 to 92 percent accuracy. Curcumin raised antioxidant enzymes in only 20 people, so that finding is early.
Sources: PMID 22194487; PMID 24222963
- Supplements studied
- 1
- Medicines and peptides
- 2
- Graded outcomes
- 5
- Trials
- 1
- People studied
- 20
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anti-Oxidant Enzyme Profile Moderate Increase | Improves (the measure goes up) | Moderate effect | 20 people | |||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 6 studies | 20 people | |||
Studies that measured oxidative stress biomarkers
| ||||||
| Pancreatitis Symptoms No effect | 1 study | 20 people | ||||
Studies that measured pancreatitis symptoms | ||||||
Prescription medicines and peptides studied, for context
Secretin (ChiRhoStim)
- Pancreatic Function Assessment: improves
- Early Pancreatitis Detection: improves
- MRCP Enhancement: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Pancreatic Function Assessment Endoscopic secretin test: peak bicarbonate <80 mEq/L indicates exocrine insufficiency. Normal response: mean peak 100 mEq/L. 79-92% diagnostic accuracy. | Improves (the measure goes up) | Large effect | 14 studies | |||
| Early Pancreatitis Detection S-MRCP detects early-stage reversible chronic pancreatitis. Signal intensity ratio <1.7 has 92% sensitivity, 75% specificity for early disease. Identifies subtle ductal abnormalities. | Improves (the measure goes up) | Large effect | 14 studies | |||
| MRCP Enhancement Secretin-enhanced MRCP increases chronic pancreatitis detection sensitivity from 77% to 89%. Improves ductal visualization 4-fold. NPV increases from 84% to 98%. | Improves (the measure goes up) | Large effect | 12 studies |
Sincalide (Kinevac)
- Pancreatic Enzyme Secretion: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Pancreatic Enzyme Secretion Combined with secretin for pancreatic function testing. Stimulates enzyme (lipase, amylase) secretion into duodenum. Used for duodenal aspirate analysis in chronic pancreatitis evaluation. | Improves (the measure goes up) | Large effect | 5 studies |
Key findings
- Anti-Oxidant Enzyme ProfileImproves (the measure goes up)
The Pancreatitis Recovery & Chronic Management Support protocol
2 primary supplements · 7 supporting supplements
- Pancreatic EnzymesPrescription PERT: 40,000–50,000 lipase units with meals, 20,000–25,000 with snacks
- Vitamin D2,000–4,000 IU daily (often higher doses needed; monitor levels)
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Pancreatitis. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
26 studies from PubMed
- Defining Biliary Hyperkinesia and the Role of Cholecystectomy
- Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues.
- The clinical value of secretin-enhanced MRCP in the functional and morphological assessment of pancreatic diseases
- Secretin-enhanced MR Imaging of the Pancreas
- The Value of Secretin-Enhanced MRCP in Patients With Recurrent Acute Pancreatitis
- Diagnostic Performance of Contrast-Enhanced MRI With Secretin-Stimulated MRCP for Non-Calcific Chronic Pancreatitis: A Comparison With Histopathology
- Quantification of pancreatic exocrine function of chronic pancreatitis with secretin-enhanced MRCP
- Optimum utilization of cholecystokinin cholescintigraphy (CCK-HIDA) in clinical practice: an evidence based review
- Secretin-enhanced MRCP: review of technique and application with proposal for quantification of exocrine function
- Gateways to clinical trials.
- Diagnostic yield of ERCP and secretin-enhanced MRCP and EUS in patients with acute recurrent pancreatitis of unknown aetiology
- Diagnosis of early-stage chronic pancreatitis by secretin-enhanced magnetic resonance cholangiopancreatography
- Secretin is an ineffective treatment for pervasive developmental disabilities: a review of 15 double-blind randomized controlled trials.
- Secretin as a treatment for autism: a review of the evidence.
- Rapid endoscopic secretin stimulation test and discrimination of chronic pancreatitis and pancreatic cancer from disease controls
- Systematic review and meta-analysis: does gall-bladder ejection fraction on cholecystokinin cholescintigraphy predict outcome after cholecystectomy in suspected functional biliary pain?
- Kinevac (sincalide for injection)/Squibb Diagnostics
- [Clinical use of secretin (literature review and personal data)].
- A randomized double-blind controlled trial comparing extra virgin coconut oil with mineral oil as a moisturizer for mild to moderate xerosis
- Efficacy of antioxidant intervention and exercise intervention for lipid peroxidation in dialysis patients: a meta-analysis.
- Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease
- Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids
- Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal
- A pilot study of the antioxidant effect of curcumin in tropical pancreatitis
- Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis
- The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.