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Condition

Zollinger-Ellison Syndrome

Zollinger-Ellison syndrome is a condition in which gastrin-producing tumors, called gastrinomas, push the stomach to make far too much acid, causing stubborn ulcers and diarrhea. Secretin, a hormone used in a clinic test, has the best-supported evidence, which is strong: studies found it detected gastrinoma with 92 to 96 percent sensitivity and 100 percent specificity. That held in properly controlled studies, though it is a test for finding tumors, not a symptom remedy.

Sources: PMID 37042078

Supplements studied
0
Medicines and peptides
1
Graded outcomes
2
No supplement studies yetWe haven’t found supplement studies for Zollinger-Ellison Syndrome. The medicines and peptides studied for it are listed below.

Prescription medicines and peptides studied, for context

These are not supplements. Most need a prescription, and some are research compounds with no approved use.

1 medicine or peptide

Secretin (ChiRhoStim)

Secretin (ChiRhoStim): outcomes studied for Zollinger-Ellison Syndrome
GradeOutcomeEffectSizeStudiesPeopleStudies list
Gastrinoma Detection

Secretin stimulation test: gastrin rise ≥120 pg/mL diagnostic for gastrinoma. Sensitivity 92-96%, specificity 100% in properly controlled studies. Preferred provocative test for ZES.

Improves (the measure goes up)Large effect9 studies

Studies that measured gastrinoma detection

and 6 more on the Secretin (ChiRhoStim) page

Diagnostic Accuracy ZES

Peak gastrin response distinguishes ZES from other hypergastrinemic states. Must discontinue PPIs to avoid false positives. Negative predictive value >95%.

Improves (the measure goes up)Large effect9 studies

Studies that measured diagnostic accuracy zes

and 6 more on the Secretin (ChiRhoStim) page

Key findings

  • Gastrinoma DetectionSecretin (ChiRhoStim)Improves (the measure goes up)
  • Diagnostic Accuracy ZESSecretin (ChiRhoStim)Improves (the measure goes up)

Safety notes in the studies

  • Must discontinue PPIs to avoid false positives.

Studies cited

9 studies from PubMed

  1. All you need to know about gastrinoma today: Gastrinoma and Zollinger-Ellison syndrome: A thorough updateBiochim Biophys Acta Rev Cancer, 2023 · PMID 37042078
  2. Secretin-enhanced MRCP: review of technique and application with proposal for quantification of exocrine functionAbdom Imaging, 2012 · PMID 22194487
  3. Diagnostic efficacy of the secretin stimulation test for the Zollinger-Ellison syndrome: an intra-individual comparison using different dosages in patients and controlsRegul Pept, 2010 · PMID 20299818
  4. Gateways to clinical trials.Methods and findings in experimental and clinical pharmacology, 2009 · PMID 19907722
  5. Secretin is an ineffective treatment for pervasive developmental disabilities: a review of 15 double-blind randomized controlled trials.Research in developmental disabilities, 2005 · PMID 15590241
  6. Secretin as a treatment for autism: a review of the evidence.Journal of autism and developmental disorders, 2004 · PMID 15628608
  7. Secretin provocation test in the diagnosis of Zollinger-Ellison syndromeAnn Intern Med, 1989 · PMID 1992623
  8. [Clinical use of secretin (literature review and personal data)].Terapevticheskii arkhiv, 1972 · PMID 4573054
  9. A randomized double-blind controlled trial comparing extra virgin coconut oil with mineral oil as a moisturizer for mild to moderate xerosisDermatitis · PMID 15724344