Condition
Sarcoidosis
Sarcoidosis is an inflammatory disease in which clusters of immune cells called granulomas form, most often in the lungs and lymph nodes, for unknown reasons. Omega-3 fatty acids and curcumin draw the most interest as anti-inflammatory options, but the evidence for both is limited, and a tiny quercetin study of 12 people found no clear difference in inflammation. Vitamin D and calcium are special cases, since granulomas can activate vitamin D and raise blood calcium.
- Supplements studied
- 1
- Graded outcomes
- 1
- Trials
- 1
- People studied
- 12
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Inflammation No effect | NoneNo effect | 12 people | ||||
| Oxidative Stress Biomarkers | Improves (the measure goes down) | 1 study | 12 people | |||
Studies that measured oxidative stress biomarkers | ||||||
Key findings
- Inflammation
The Sarcoidosis Supportive Care protocol
2 primary supplements · 3 supporting supplements
- Omega-3 Fatty Acids2–4 g EPA+DHA daily
- Curcumin1,000–2,000 mg daily with piperine
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Sarcoidosis. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
9 studies from PubMed
- Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis
- No evidence for a thermic effect of the dietary flavonol quercetin: a pilot study in healthy normal-weight women
- No effect of nutritional adenosine receptor antagonists on exercise performance in the heat
- Thermotolerance and heat acclimation may share a common mechanism in humans
- Effect of quercetin supplementation on repeated-sprint performance, xanthine oxidase activity, and inflammation
- Quercetin in the treatment of dyslipidemia
- Effects of 6 weeks of quercetin supplementation on energy, fatigue, and sleep in ROTC cadets
- The Impact of Three-Month Quercetin Intake on Quality of Life and Anxiety in Patients With Type II Diabetes Mellitus: An Early Data Analysis From a Randomized Controlled Trial.
- Benefits of Quercetin on Glycated Hemoglobin, Blood Pressure, PiKo-6 Readings, Night-Time Sleep, Anxiety, and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.