Condition
Stable Angina
Stable angina is predictable chest pain or pressure during exertion or stress, caused by too little blood reaching the heart muscle. Coenzyme Q10 and L-carnitine have the strongest evidence, rated moderate, and both are thought to support the heart's energy supply; L-carnitine trials have been pooled in a meta-analysis. Still, a single study of Terminalia arjuna found no clear difference in exercise tolerance, and evidence for it is very limited.
Sources: PMID 11502782
- Supplements studied
- 4
- Graded outcomes
- 3
- Trials
- 2
- People studied
- 540
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| C-Reactive Protein (CRP) Small Decrease | Improves (the measure goes down) | Small effect | 3 studies | 147 people | ||
Studies that measured c-reactive protein (crp)
| ||||||
| Interleukin 6 | Improves (the measure goes down) | 225 people | ||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anxiety Symptoms Large Improvement | Improves (the measure goes down) | Large effect | 2 studies | 80 people | ||
| Depression Symptoms | Improves (the measure goes down) | 1 study | 80 people | |||
Studies that measured depression symptoms | ||||||
| Stress Signs and Symptoms | Improves (the measure goes down) | 1 study | 80 people | |||
Studies that measured stress signs and symptoms | ||||||
| Sleep Disturbance Signs and Symptoms | Improves (the measure goes down) | 80 people | ||||
| Sleep Duration | Improves (the measure goes up) | 80 people | ||||
| Sleep Efficiency | Improves (the measure goes up) | 80 people | ||||
| Sleep Latency | Improves (the measure goes down) | 80 people | ||||
| Sleep Quality | Improves (the measure goes up) | 80 people | ||||
Terminalia Arjuna
- Exercise Tolerance
- ST-segment depression: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Exercise Tolerance No effect | NoneNo effect | 1 study | 133 people | |||
Studies that measured exercise tolerance | ||||||
| ST-segment depression | Improves (the measure goes down) | 133 people | ||||
Cannabis
- Heart Rate: improves
- Blood Pressure: improves
- Angina: worsens
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Heart Rate | Improves (the measure goes down) | 4 studies | 10 people | |||
| Blood Pressure | Improves (the measure goes down) | 1 study | 10 people | |||
Studies that measured blood pressure | ||||||
| Angina Moderate Detriment | Worsens (the measure goes down) | Moderate effect | 10 people | |||
Key findings
- C-Reactive Protein (CRP)Improves (the measure goes down)
- Anxiety SymptomsImproves (the measure goes down)
- Exercise Tolerance
The Stable Angina Supportive Care protocol
2 primary supplements · 3 supporting supplements
- Coenzyme Q10100–300 mg daily
- L-Carnitine2–3 g daily
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Stable Angina. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
The collection holds the supplements we grade A or B for its theme, in products from the Fullscript catalog. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
Or shop one supplement
The supplement graded A or B for Stable Angina. Each opens the products we list for that supplement.
- Grade B
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Studies cited
13 studies from PubMed
- Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis.
- The effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.
- Can resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials.
- Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.
- The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina
- The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis
- Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm)
- Effects of lozenge containing lavender oil, extracts from hops, lemon balm and oat on electrical brain activity of volunteers
- Middle cerebral artery velocity during upright posture after marijuana smoking
- The effects of smoking marihuana on physical performance
- Regional cerebral blood flow after marijuana smoking
- Effect of marihuana on intraocular and blood pressure in glaucoma
- Effects of acute marijuana smoking on pulse rate and mood states in women