Condition
Tobacco Use Disorder
Tobacco use disorder, often called nicotine addiction, is a condition in which nicotine creates strong physical and psychological dependence, which is why quitting is so hard. Little research on supplements for it has been reviewed here so far, so there are no trial findings to report for NAC or vitamin C, the two most often discussed. Both have only limited evidence behind them, and ideas about cravings or oxidative stress remain largely theoretical for now.
- Supplements studied
- 2
- Graded outcomes
- 0
- Trials
- 2
- People studied
- 37
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Tobacco Consumption | Improves (the measure goes up) | 2 studies | 8 people | |||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Tobacco Addiction Symptoms | Improves (the measure goes down) | 1 study | 29 people | |||
Studies that measured tobacco addiction symptoms | ||||||
The Tobacco Use Disorder (Smoking Cessation) Support protocol
2 primary supplements · 4 supporting supplements
- NAC (N-Acetyl Cysteine)1,200–2,400 mg daily in divided doses
- Vitamin C500–1,000 mg daily
Studies cited
3 studies from PubMed
- The role of cystine-glutamate exchange in nicotine dependence in rats and humans
- Impact of smoked cannabis on tobacco cigarette smoking intensity and subjective effects: A placebo-controlled, double-blind, within-subjects human laboratory study
- Smoked marijuana effects on tobacco cigarette smoking behavior