Supplement
Creatinol O-phosphate is a compound related to creatine that heart muscle cells can use in their energy metabolism. People mostly look at it for heart rhythm problems, and human trials from the late 1970s found that injected doses reduced extra ventricular beats in people with ischemic heart disease, with moderate evidence. Those studies were small, all used injections rather than oral forms, and the other heart findings rest mostly on animal or lab work.
Sources: PMID 395959; PMID 575497
- Updated
- How we grade
- 12 studies cited
- Best evidence
- Grade B
- Conditions studied
- 3
- Outcomes
- 3
- Graded outcomes
- 0111
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Ventricular Arrhythmia Reduction (IV Administration) Multiple human clinical trials from the late 1970s, including double-blind studies, found that intravenous COP (1-3g) reduced ventricular premature beats and showed antiarrhythmic effectiveness in patients with ischemic heart disease. All evidence is limited to IV injection; no data exists for oral administration. | Improves (the measure goes down) | Moderate effect | 6 studies | 100 people | ||
Studies that measured ventricular arrhythmia reduction (iv administration)
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| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Myocardial Ischemia Protection (IV Administration) A double-blind clinical trial found IV COP improved outcomes in patients with inadequate coronary circulation. Animal studies in rats and mice showed COP protected against isoprenaline-induced cardiac enzyme elevation and CaCl2-induced ventricular fibrillation. An in vitro NMR study in perfused Xenopus heart confirmed effects on cardiac energy metabolism. All evidence is from IV or direct perfusion, not oral dosing. | Improves (the measure goes up) | Moderate effect | 7 studies | 80 people | ||
Studies that measured myocardial ischemia protection (iv administration)
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| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Cardiac Hemodynamic Function (IV Administration) A single preclinical study in conscious and anaesthetized dogs examined the effects of IV COP on haemodynamics and cardiac metabolism, providing early evidence of cardiovascular activity. No human replication or oral bioavailability data exists. | Improves (the measure goes up) | Small effect | 3 studies | |||
Studies that measured cardiac hemodynamic function (iv administration) | ||||||
Key findings
- Ventricular Arrhythmia Reduction (IV Administration)Improves (the measure goes down)
- Myocardial Ischemia Protection (IV Administration)Improves (the measure goes up)
- Cardiac Hemodynamic Function (IV Administration)Improves (the measure goes up)
Studies cited
12 studies from PubMed
- A 31P NMR spectroscopy study of Xenopus laevis heart perfused in vitro with creatinol-O-phosphate, phosphocreatine, adenosine triphosphate, fructose diphosphate and ouabain.
- Antiarrhythmic effectiveness of creatinol O-phosphate in man.
- Pharmacological and toxicological properties of creatinol O-phosphate. A review.
- Creatinol O-phosphate therapy in patients with inadequate coronary circulation. Double blind clinical trial.
- Activity of creatinol O-phosphate on persistent ventricular premature beats in ischemic heart disease. Double blind clinical trial.
- Acute clinical tolerance of creatinol O-phosphate.
- Protective action of creatinol O-phosphate against serum CPK activity enhanced by isoprenaline in the rat.
- Protective effect of creatinol O-phosphate (COP) on ventricular fibrillation and death induced by intravenous CaCl2 in mice.
- Protective effect of creatinol O-phosphate (COP) on some experimental arrhythmias in vitro and in vivo.
- Effects of creatinol O-phosphate on serum enzymes in acute myocardial infarction.
- Preliminary report on electrophysiological effectiveness of creatinol O-phosphate (COP) in human subjects.
- Effects of creatinol-O-phosphate (COP) on haemodynamics and cardiac metabolism in conscious and anaesthetized dogs.