Condition
Agoraphobia
Agoraphobia is an anxiety disorder in which people fear and avoid places like public transport, crowds, or being outside alone, because escape or help might feel out of reach if panic strikes. Among supplements, inositol has the most research behind it, and small trials found anxiety symptoms eased in people with panic-related fears. Those studies were tiny, about 21 people across three studies, so the evidence is limited and firm conclusions aren't possible yet.
Sources: PMID 11386498
- Supplements studied
- 2
- Graded outcomes
- 2
- Trials
- 2
- People studied
- 162
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anxiety Symptoms Small Improvement | Improves (the measure goes down) | Small effect | 3 studies | 21 people | ||
| Panic Attacks | Improves (the measure goes down) | 1 study | 21 people | |||
Studies that measured panic attacks | ||||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Aggression Small Improvement | Improves (the measure goes up) | Small effect | 141 people | |||
| Anxiety Symptoms | Improves (the measure goes down) | 7 studies | 141 people | |||
| Subjective Well-Being | Improves (the measure goes up) | 3 studies | 141 people | |||
Studies that measured subjective well-being
| ||||||
| Liver Enzymes | Changes; see studies | 141 people | ||||
Key findings
- Anxiety SymptomsImproves (the measure goes down)
- AggressionImproves (the measure goes up)
The Agoraphobia Supportive Care protocol
2 primary supplements · 7 supporting supplements
- Inositol12–18 g daily in divided doses (start lower, titrate up)
- Lavender Oil (Silexan)80–160 mg Silexan (standardized lavender oil) daily
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Studies cited
14 studies from PubMed
- The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum
- A placebo-controlled study of Kava kava in generalized anxiety disorder
- Efficacy of kava extract for treating anxiety: systematic review and meta-analysis.
- Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.
- Kava treatment in patients with anxiety
- Clinical efficacy of kava extract WS 1490 in sleep disturbances associated with anxiety disorders. Results of a multicenter, randomized, placebo-controlled, double-blind clinical trial
- Kava extract for treating anxiety
- Efficacy of kava-kava in the treatment of non-psychotic anxiety, following pretreatment with benzodiazepines
- Treatment of anxiety, tension and restlessness states with Kava special extract WS 1490 in general practice: a randomized placebo-controlled double-blind multicenter trial
- Kava-kava extract WS 1490 versus placebo in anxiety disorders--a randomized placebo-controlled 25-week outpatient trial
- Acute inositol does not attenuate m-CPP-induced anxiety, mydriasis and endocrine effects in panic disorder
- Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder
- Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder
- Effect of inositol on bulimia nervosa and binge eating