Condition
Hyperuricemia
Hyperuricemia means too much uric acid in the blood, produced when the body breaks down purines from certain foods and drinks, and it can lead to gout and kidney stones. Vitamin C and tart cherry extract have moderate evidence, and vitamin C lowered uric acid in studies. A small trial of tart cherry concentrate found no clear difference in gout symptoms, and IP6 lowered uric acid in only 25 people.
Sources: PMID 31891407; PMID 31119466
- Supplements studied
- 5
- Graded outcomes
- 4
- Trials
- 6
- People studied
- 442
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Uric Acid Small Decrease | Improves (the measure goes down) | Small effect | 1 study | 25 people | ||
Tart Cherry Juice
- Gout Symptoms
- Uric Acid: improves
- HbA1c: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Gout Symptoms No effect | NoneNo effect | 1 study | 50 people | |||
Studies that measured gout symptoms | ||||||
| Uric Acid | Improves (the measure goes down) | 2 studies | 50 people | |||
| HbA1c | Improves (the measure goes down) | 50 people | ||||
Riboflavin (Vitamin B2)
- C-Reactive Protein (CRP)
- Homocysteine: improves
- Ferritin: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| C-Reactive Protein (CRP) No effect | NoneNo effect | 42 people | ||||
| Homocysteine | Improves (the measure goes down) | 4 studies | 42 people | |||
Studies that measured homocysteine | ||||||
| Ferritin | Improves (the measure goes up) | 42 people | ||||
| Uric Acid | Improves (the measure goes down) | 42 people | ||||
Vitamin C
- Uric Acid: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Uric Acid | Improves (the measure goes down) | 2 studies | 184 people | |||
Key findings
- Blood glucoseImproves (the measure goes down)
- Uric AcidImproves (the measure goes down)
- Gout Symptoms
The Hyperuricemia (High Uric Acid) Management protocol
2 primary supplements · 5 supporting supplements
- Vitamin C500–1,500 mg daily
- Tart Cherry Extract240–480 ml juice daily or 500–1,000 mg extract
Shop the evidence-backed picks
Fullscript collectionMetabolic health: evidence-graded picksOpen on Fullscript
The collection holds the supplements we grade A or B for its theme, in products from the Fullscript catalog. It opens in our Fullscript store. You can look through it without signing in; Fullscript asks for a free account to order.
We earn from purchases made in our Fullscript store, and links to Fullscript, iHerb or Thorne carry our referral, so we may earn a commission at no extra cost to you. Grades come from the research and never change based on what we earn. Full disclosure
Studies cited
49 studies from PubMed
- The Effect of Antioxidant Polyphenol Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis.
- Curcumin alleviates postprandial glycaemic response in healthy subjects: A cross-over, randomized controlled study
- Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects
- Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects
- Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study
- Association between Oral vitamin C supplementation and serum uric acid: A meta-analysis of randomized controlled trials
- The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trial
- Riboflavin supplementation to patients with multiple sclerosis does not improve disability status nor is riboflavin supplementation correlated to homocysteine
- Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism
- Riboflavin supplementation and biomarkers of cardiovascular disease in the elderly
- Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status
- Thirty Days of Montmorency Tart Cherry Supplementation Has No Effect on Gut Microbiome Composition, Inflammation, or Glycemic Control in Healthy Adults
- Lack of effect of tart cherry concentrate dose on serum urate in people with gout
- Consumption of 100% Tart Cherry Juice Reduces Serum Urate in Overweight and Obese Adults
- Effect of Inositol Hexaphosphate (IP 6) on Serum Uric Acid in Hyperuricemic Subjects: a Randomized, Double-Blind, Placebo-Controlled, Crossover Study
- The effect of curcumin on lipid level in patients with acute coronary syndrome
- Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial
- Effects of Nanocurcumin Supplementation on Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study
- Influence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approach
- Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women
- Effects of Curcumin on Postmenopausal Women's Health: A Systematic Review and Meta-Analysis.
- Curcumin on Human Health: A Comprehensive Systematic Review and Meta-Analysis of 103 Randomized Controlled Trials.
- Curcumin extract for prevention of type 2 diabetes
- Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double-blind placebo- controlled clinical trial
- Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial
- Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial
- The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial
- Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies
- Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial
- The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial
- Curcumin effects on blood lipid profile in a 6-month human study
- Effects of supplementation with curcuminoids on dyslipidemia in obese patients: a randomized crossover trial
- Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people
- Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial
- Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial
- Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD
- Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial
- Effect of turmeric on glycemic status, lipid profile, hs-CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients
- Effect of Curcumin on Serum Urate in Asymptomatic Hyperuricemia: A Randomized Placebo-Controlled Trial
- The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial
- Bread enriched with phytosterols with or without curcumin modulates lipoprotein profiles in hypercholesterolaemic individuals. A randomised controlled trial
- Effects of curcumin/turmeric supplementation on lipid profile: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.
- Efficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic Patients
- Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidemic individuals
- Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis
- Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial
- Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial
- The effects of curcumin supplementation on liver enzymes, lipid profile, glucose homeostasis, and hepatic steatosis and fibrosis in patients with non-alcoholic fatty liver disease