Condition

Inflammatory Venous Disease

Inflammatory venous disease, including chronic venous insufficiency and varicose veins, happens when inflamed, weakened veins and damaged valves let blood pool in the legs, causing swelling, pain and skin changes. Horse chestnut seed extract and diosmin-hesperidin have the strongest evidence, and in one small trial of 40 people, serrapeptase improved pain. Still, the serrapeptase evidence is limited, and compression stockings and exercise remain the foundation.

Sources: PMID 2688125

Supplements studied: 1
Graded outcomes: 1
Trials: 1
People studied: 40

Evidence by supplement

Strong
Moderate
Limited
Very limited

1 supplement

Serrapeptase

Serrapeptase: outcomes studied for Inflammatory Venous Disease
Grade	Outcome	Effect	Size	Studies	People
	Pain Small Improvement	Improves (the measure goes down)	Small effect	1 study	40 people
Studies that measured pain The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trialSingapore Med J · PMID 2688125
	Superficial Thrombophlebitis Symptoms	Improves (the measure goes down)		1 study	40 people
Studies that measured superficial thrombophlebitis symptoms [Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase]Minerva Cardioangiol · PMID 9091835

Key findings

PainSerrapeptaseImproves (the measure goes down)

The Inflammatory Venous Disease Support protocol

2 primary supplements · 6 supporting supplements

Horse Chestnut Seed Extract (Aescin)300 mg standardized extract (50 mg aescin) twice daily
Diosmin-Hesperidin (Micronized Purified Flavonoid Fraction)500 mg twice daily or 1,000 mg once daily

See the full protocol

Shop the evidence-backed picks

Support alongside medical care. These supplements are not a treatment for Inflammatory Venous Disease. If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.

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Studies cited

2 studies from PubMed

[Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase]Minerva Cardioangiol · PMID 9091835
The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trialSingapore Med J · PMID 2688125