Supplement
Aged garlic extract is made by soaking sliced garlic for months, which turns its harsh compounds into gentler sulfur compounds that may help blood vessels relax. The evidence is strongest for blood pressure, where a meta-analysis found systolic pressure fell by about 8 mmHg in people with high blood pressure. Those results come from roughly 550 people with hypertension, and the evidence for cholesterol was more limited.
- Updated
- How we grade
- 4 studies cited
- Best evidence
- Grade A
- Conditions studied
- 3
- Outcomes
- 10
- Graded outcomes
- 1540
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Systolic Blood Pressure 8.3 mmHg reduction in hypertensives (meta-analysis) | Improves (the measure goes down) | Large effect | 553 people | |||
| Diastolic Blood Pressure 5.5 mmHg reduction in hypertensives | Improves (the measure goes down) | Moderate effect | 553 people | |||
| Arterial Stiffness Reduced pulse wave velocity by 0.7 m/sec | Improves (the measure goes down) | Moderate effect | 180 people | |||
| Coronary Artery Calcification Progression Slowed CAC progression vs placebo | Improves (the measure goes down) | Moderate effect | 200 people | |||
| Low Attenuation Plaque Significant reduction in soft plaque volume | Improves (the measure goes down) | Large effect | 110 people | |||
| Central Blood Pressure Significant reduction in uncontrolled hypertension | Improves (the measure goes down) | Moderate effect | 88 people | |||
| Total Cholesterol 10% reduction in elevated cholesterol | Improves (the measure goes down) | Small effect | 400 people | |||
| LDL Cholesterol 4.4 mg/dL reduction (meta-analysis) | Improves (the measure goes down) | Small effect | 400 people |
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Inflammatory Markers Reduced inflammatory cytokines | Improves (the measure goes down) | Moderate effect | 150 people |
Blood Sugar
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Fasting Glucose Modest reduction in diabetic patients | Improves (the measure goes down) | Small effect | 120 people |
Key findings
- Systolic Blood PressureImproves (the measure goes down)
- Diastolic Blood PressureImproves (the measure goes down)
- Arterial StiffnessImproves (the measure goes down)
Studies cited
4 studies from PubMed
- Aged garlic extract reduces left ventricular myocardial mass in patients with diabetes
- Randomized trial evaluating the effect of aged garlic extract with supplements versus placebo on adipose tissue surrogates for coronary atherosclerosis progression
- Aged Garlic Extract Reduces Low Attenuation Plaque in Coronary Arteries of Patients with Metabolic Syndrome in a Prospective Randomized Double-Blind Study
- Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis