Condition
Antidepressant-Induced Sexual Dysfunction (AISD)
Antidepressant-induced sexual dysfunction is a common side effect of SSRIs and SNRIs, where extra serotonin dampens dopamine and norepinephrine pathways, lowering libido and arousal or delaying orgasm. Maca and saffron are the supplements studied most directly for it, though little research on them has been reviewed here so far. Ginkgo, L-arginine and ashwagandha have drawn interest too, but their evidence is limited, so it is early to say how well any work.
Sources: PMID 18801111; PMID 23280545
- Supplements studied
- 2
- Graded outcomes
- 0
- Trials
- 2
- People studied
- 82
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Libido | Improves (the measure goes up) | 4 studies | 37 people | |||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Sexual Function | Improves (the measure goes up) | 2 studies | 45 people | |||
The Antidepressant-Induced Sexual Dysfunction Support protocol
2 primary supplements · 5 supporting supplements
Shop the evidence-backed picks
Support alongside medical care. These supplements are not a treatment for Antidepressant-Induced Sexual Dysfunction (AISD). If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.
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Studies cited
6 studies from PubMed
- A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction
- A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women
- A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction
- Short- and long-term effects of Ginkgo biloba extract on sexual dysfunction in women
- Triple-blind, placebo-controlled trial of Ginkgo biloba in sexual dysfunction due to antidepressant drugs
- Ginkgo biloba for antidepressant-induced sexual dysfunction