Condition
Male Sexual Dysfunction
Erectile dysfunction is trouble getting or keeping an erection, often because blood flow to the penis is reduced. Korean red ginseng has the best support, with trials finding that erections went up and the evidence rated moderate; yohimbine and saffron also showed improvements, though that evidence is limited. Those studies were small, with about 200 people across the ginseng trials, so the results are preliminary.
Sources: PMID 12394711; PMID 8750052
- Supplements studied
- 16
- Graded outcomes
- 16
- Trials
- 24
- People studied
- 2,436
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Erections Small Increase | Improves (the measure goes up) | Small effect | 4 studies | 195 people | ||
Studies that measured erections | ||||||
| Testosterone | Improves (the measure goes up) | 1 study | 60 people | |||
Studies that measured testosterone | ||||||
| High-density lipoprotein (HDL) | Improves (the measure goes up) | 60 people | ||||
| Low-density lipoprotein (LDL) | Improves (the measure goes down) | 60 people | ||||
| Prolactin | Improves (the measure goes up) | 60 people | ||||
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Benign Prostatic Hyperplasia Symptoms Small Improvement | Improves (the measure goes down) | Small effect | 7 studies | 82 people | ||
Studies that measured benign prostatic hyperplasia symptoms
| ||||||
| Quality of Life | Improves (the measure goes up) | 82 people | ||||
| Sexual Function | Improves (the measure goes up) | 82 people | ||||
Saffron
- Erections: improves
- Sexual Function: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Erections Small Increase | Improves (the measure goes up) | Small effect | 4 studies | 396 people | ||
Studies that measured erections
| ||||||
| Sexual Function | Improves (the measure goes up) | 2 studies | 50 people | |||
Tribulus Terrestris
- Erections: improves
- Testosterone
- Luteinizing Hormone
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Erections Small Increase | Improves (the measure goes up) | Small effect | 4 studies | 30 people | ||
Studies that measured erections
| ||||||
| Testosterone No effect | 1 study | |||||
Studies that measured testosterone | ||||||
| Luteinizing Hormone | ||||||
Maca
- Estrogen: worsens
- Follicle-Stimulating Hormone: improves
- Libido: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Estrogen Small Increase | Worsens (the measure goes up) | Small effect | 1 study | 56 people | ||
| Follicle-Stimulating Hormone | Improves (the measure goes up) | 3 studies | 56 people | |||
Studies that measured follicle-stimulating hormone
| ||||||
| Libido | Improves (the measure goes up) | 1 study | 8 people | |||
| Testosterone | Improves (the measure goes up) | 1 study | 56 people | |||
Studies that measured testosterone | ||||||
| Luteinizing Hormone | Improves (the measure goes up) | 56 people | ||||
| Prolactin | Improves (the measure goes up) | 56 people | ||||
Yohimbine
- Erections: improves
- Penile Girth: improves
- Testosterone: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Erections Small improvement in erectile function | Improves (the measure goes up) | Small effect | 1 study | 419 people | ||
Studies that measured erections | ||||||
| Penile Girth Small improvement during erection | Improves (the measure goes up) | Small effect | 18 people | |||
| Testosterone | Improves (the measure goes up) | 1 study | 18 people | |||
Studies that measured testosterone | ||||||
Shilajit
- Follicle-Stimulating Hormone: improves
- Oxidative Stress Biomarkers: changes; see studies
- Luteinizing Hormone: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Follicle-Stimulating Hormone Small Increase | Improves (the measure goes up) | Small effect | 60 people | |||
| Oxidative Stress Biomarkers | Changes; see studies | 1 study | 60 people | |||
Studies that measured oxidative stress biomarkers | ||||||
| Luteinizing Hormone | Improves (the measure goes up) | 60 people | ||||
| Sperm Quality | Improves (the measure goes up) | 60 people | ||||
| Testosterone | Improves (the measure goes up) | 60 people | ||||
Fenugreek
- Libido: improves
- Prostate-Specific Antigen: improves
- Prolactin: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Libido Moderate Increase | Improves (the measure goes up) | Moderate effect | 60 people | |||
| Prostate-Specific Antigen | Improves (the measure goes up) | 1 study | 60 people | |||
Studies that measured prostate-specific antigen | ||||||
| Prolactin | Improves (the measure goes up) | 60 people | ||||
| Testosterone | Improves (the measure goes up) | 60 people | ||||
Butea Superba
- Erections
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Erections No effect | NoneNo effect | 2 studies | 70 people | |||
Nicotine
- Blood Pressure
- Libido: improves
- Penile Girth: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Blood Pressure No effect | NoneNo effect | 2 studies | 28 people | |||
| Libido | Improves (the measure goes up) | 1 study | 28 people | |||
| Penile Girth | Improves (the measure goes up) | 28 people | ||||
Ashwagandha
- Erections
- Testosterone: improves
- Sperm Quality: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Erections No effect | NoneNo effect | 1 study | 86 people | |||
Studies that measured erections | ||||||
| Testosterone | Improves (the measure goes up) | 5 studies | 46 people | |||
Studies that measured testosterone
| ||||||
| Sperm Quality | Improves (the measure goes up) | 1 study | 46 people | |||
| Luteinizing Hormone | Improves (the measure goes up) | 46 people | ||||
| Seminal Motility | Improves (the measure goes up) | 46 people | ||||
| Sperm Count | Improves (the measure goes up) | 46 people | ||||
Velvet Antler
- Follicle-Stimulating Hormone
- Testosterone: improves
- Free Testosterone: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Follicle-Stimulating Hormone No effect | NoneNo effect | 1 study | 24 people | |||
Studies that measured follicle-stimulating hormone | ||||||
| Testosterone | Improves (the measure goes up) | 1 study | 24 people | |||
Studies that measured testosterone | ||||||
| Free Testosterone | Improves (the measure goes up) | 24 people | ||||
| Libido | Improves (the measure goes up) | 48 people | ||||
| Luteinizing Hormone | Improves (the measure goes up) | 24 people | ||||
| Prolactin | Improves (the measure goes up) | 24 people | ||||
| Sexual Function | Improves (the measure goes up) | 24 people | ||||
DHEA
- Erections
- Testosterone: improves
- Serum DHEA: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Erections No effect | NoneNo effect | 79 people | ||||
| Testosterone | Improves (the measure goes up) | 3 studies | 79 people | |||
| Serum DHEA | Improves (the measure goes up) | 2 studies | 79 people | |||
| Libido | ||||||
| Prostate-Specific Antigen | Improves (the measure goes up) | 79 people |
L-Carnitine
- Benign Prostatic Hyperplasia Symptoms
- Sperm Quality: improves
- Depression Symptoms: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Benign Prostatic Hyperplasia Symptoms No effect | NoneNo effect | 120 people | ||||
| Sperm Quality | Improves (the measure goes up) | 10 studies | 459 people | |||
| Depression Symptoms | Improves (the measure goes down) | 2 studies | 120 people | |||
| Erections | Improves (the measure goes up) | 2 studies | 256 people | |||
| Prostate-Specific Antigen No effect | 1 study | 120 people | ||||
| Sexual Function | Improves (the measure goes up) | 1 study | 216 people | |||
| Fatigue Symptoms | Improves (the measure goes down) | 120 people | ||||
| Fertility | ||||||
| Free Testosterone | Improves (the measure goes up) | 120 people | ||||
| Luteinizing Hormone | Improves (the measure goes up) | 120 people | ||||
| Sperm Count | ||||||
| Testosterone | Improves (the measure goes up) | 120 people |
Ginkgo Biloba
- Depression Symptoms
- Libido: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Depression Symptoms No effect | NoneNo effect | 24 people | ||||
| Libido | Improves (the measure goes up) | 4 studies | 24 people |
Pycnogenol
- Erections: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Erections | Improves (the measure goes up) | 1 study | 40 people |
Key findings
- ErectionsImproves (the measure goes up)
- Benign Prostatic Hyperplasia SymptomsImproves (the measure goes down)
- EstrogenWorsens (the measure goes up)
The Male Sexual Dysfunction (Erectile Dysfunction) protocol
2 primary supplements · 5 supporting supplements
- L-Citrulline1.5–3 g daily (or 6–8 g citrulline malate)
- Panax Ginseng (Korean Red Ginseng)900–1,800 mg Korean red ginseng daily
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Studies cited
73 studies from PubMed
- Tribulus terrestris for management of patients with erectile dysfunction: a systematic review and meta-analysis of randomized trials.
- Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials
- Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial
- Effect of deer velvet on sexual function in men and their partners: a double-blind, placebo-controlled study
- Effect of elk velvet antler supplementation on the hormonal response to acute and chronic exercise in male and female rowers
- Evaluation of the efficacy and safety of Tribulus terrestris in male sexual dysfunction-A prospective, randomized, double-blind, placebo-controlled clinical trial
- Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use.
- Pilot Study on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Erectile Function in Aging Males With Partial Androgen Deficiency (PADAM)
- Tribulus terrestris versus placebo in the treatment of erectile dysfunction and lower urinary tract symptoms in patients with late-onset hypogonadism: A placebo-controlled study
- Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia
- Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms
- Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial
- Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial
- Saw palmetto for benign prostatic hyperplasia
- Observational database serenoa repens (DOSSER): overview, analysis and results. A multicentric SIUrO (Italian Society of Oncological Urology) project
- Serenoa repens extract for benign prostate hyperplasia: a randomized controlled trial
- Serenoa repens monotherapy for benign prostatic hyperplasia (BPH): an updated Cochrane systematic review
- An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment
- Effects of saffron (Crocus sativus) on sexual dysfunction among men and women: A systematic review and meta-analysis.
- Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study
- A systematic review and meta-analysis of clinical trials on saffron (Crocus sativus) effectiveness and safety on erectile dysfunction and semen parameters.
- Effects of a Topical Saffron (Crocus sativus L) Gel on Erectile Dysfunction in Diabetics: A Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Trial
- Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study
- Treatment of erectile dysfunction with pycnogenol and L-arginine
- Effects of Panax Ginseng C.A. Meyer saponins on male fertility
- Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction
- Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction
- Clinical efficacy of Korean red ginseng for erectile dysfunction
- A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: a preliminary report
- Acute effects of nicotine on physiological and subjective sexual arousal in nonsmoking men: a randomized, double-blind, placebo-controlled trial
- Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial
- The inhibitory effects of nicotine on physiological sexual arousal in nonsmoking women: results from a randomized, double-blind, placebo-controlled, cross-over trial
- Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial
- A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen
- Effect of Lepidium meyenii Walp. on Semen Parameters and Serum Hormone Levels in Healthy Adult Men: A Double-Blind, Randomized, Placebo-Controlled Pilot Study
- Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men
- Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men
- Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content
- A placebo-controlled, double-blind trial of Ginkgo biloba for antidepressant-induced sexual dysfunction
- Short- and long-term effects of Ginkgo biloba extract on sexual dysfunction in women
- Triple-blind, placebo-controlled trial of Ginkgo biloba in sexual dysfunction due to antidepressant drugs
- Ginkgo biloba for antidepressant-induced sexual dysfunction
- Physiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum-graecum Extract and Mineral Formulation
- A dose-response and meta-analysis of dehydroepiandrosterone (DHEA) supplementation on testosterone levels: perinatal prediction of randomized clinical trials.
- Androgens and sexual function: a placebo-controlled, randomized, double-blind study of testosterone vs. dehydroepiandrosterone in men with sexual dysfunction and androgen deficiency
- Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment
- Effect of acute DHEA administration on free testosterone in middle-aged and young men following high-intensity interval training
- Effects of dehydroepiandrosterone vs androstenedione supplementation in men
- L-Acetylcarnitine in dysthymic disorder in elderly patients: a double-blind, multicenter, controlled randomized study vs. fluoxetine
- Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis
- Propionyl-L-carnitine, L-arginine and niacin in sexual medicine: a nutraceutical approach to erectile dysfunction
- Combination effect of Pentoxifylline and L-carnitine on idiopathic oligoasthenoteratozoospermia
- Carnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trial
- Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study
- Oral carnitine supplementation increases sperm motility in asthenozoospermic men with normal sperm phospholipid hydroperoxide glutathione peroxidase levels
- Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial
- Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia
- Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial
- Does L-carnitine therapy add any extra benefit to standard inguinal varicocelectomy in terms of deoxyribonucleic acid damage or sperm quality factor indices: a randomized study
- Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia
- l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility.
- Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy
- Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging
- Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes
- The use of Butea superba (Roxb.) compared to sildenafil for treating erectile dysfunction
- Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction
- Efficacy of Ashwagandha (Withania somnifera Dunal. Linn.) in the management of psychogenic erectile dysfunction
- Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trial
- Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study
- Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males
- Withania somnifera Improves Semen Quality in Stress-Related Male Fertility
- Efficacy of Withania somnifera on seminal plasma metabolites of infertile males: a proton NMR study at 800 MHz
- Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial