Condition
Paranoia
Paranoia is a pattern of persistent, unfounded beliefs that others mean you harm, such as feeling watched, followed or talked about, and it can arise from severe stress, sleep loss, substance use, or conditions like schizophrenia and bipolar disorder. Little research on supplements for it has been reviewed here so far, so there are no trial findings to report yet. Omega-3 fatty acids and vitamin D have been looked at most often in related psychosis research, but that work isn't specific to paranoia.
- Supplements studied
- 1
- Graded outcomes
- 0
- Trials
- 1
- People studied
- 32
Evidence by supplement
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Anxiety Symptoms | Improves (the measure goes down) | 5 studies | 32 people | |||
Studies that measured anxiety symptoms
| ||||||
The Paranoia Supportive Care protocol
2 primary supplements · 6 supporting supplements
- Omega-3 Fatty Acids2–4 g EPA+DHA daily (higher EPA ratio)
- Vitamin D2,000–4,000 IU daily (target 40–60 ng/mL)
Studies cited
5 studies from PubMed
- Effects of ipsapirone and cannabidiol on human experimental anxiety
- Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects
- Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life
- The effects of cannabidiol on persecutory ideation and anxiety in a high trait paranoid group
- Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test