Supplement
Manganese is a trace mineral that helps build bone and powers enzymes such as manganese superoxide dismutase, which protects cells from oxidative damage. The evidence is strongest in people with low manganese, where studies found blood manganese levels and MnSOD levels went up. Findings for bone density, oxidative stress markers, PMS symptoms and wound closure are only moderate, and those studies were small to moderate in size.
- Updated
- How we grade
- Best evidence
- Grade B
- Conditions studied
- 8
- Outcomes
- 14
- Graded outcomes
- 0360
Evidence by condition
- Strong
- Moderate
- Limited
- Very limited
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Bone Mineral Density Small Increase | Improves (the measure goes up) | Small effect | 350 people | |||
| Bone Formation Markers Moderate Increase | Improves (the measure goes up) | Moderate effect | 240 people |
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| PMS Symptoms Moderate Decrease | Improves (the measure goes down) | Moderate effect | 180 people |
Glucose Metabolism
- Insulin Sensitivity
- Fasting Blood Glucose
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Insulin Sensitivity Mixed effect | 2 studies | |||||
Studies that measured insulin sensitivity | ||||||
| Fasting Blood Glucose Mixed effect | 2 studies | |||||
Studies that measured fasting blood glucose
| ||||||
Antioxidant Status
- MnSOD Activity: improves
- Oxidative Stress Markers
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| MnSOD Activity | Improves (the measure goes up) | 1 study | ||||
Studies that measured mnsod activity | ||||||
| Oxidative Stress Markers | ||||||
Epilepsy
- Seizure Frequency: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Seizure Frequency Small Decrease | Improves (the measure goes down) | Small effect | 80 people |
Osteoarthritis (OA)
- Joint Pain: improves
- Cartilage Health: improves
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Joint Pain Small Decrease | Improves (the measure goes down) | Small effect | 200 people | |||
| Cartilage Health Small Increase | Improves (the measure goes up) | Small effect | 120 people |
Wound Healing
- Wound Closure Rate
- Collagen Synthesis
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Wound Closure Rate | ||||||
| Collagen Synthesis |
Manganese Deficiency
- Serum Manganese Levels
- MnSOD Levels
| Grade | Outcome | Effect | Size | Studies | People | Studies list |
|---|---|---|---|---|---|---|
| Serum Manganese Levels | ||||||
| MnSOD Levels |
Key findings
- Bone Mineral DensityImproves (the measure goes up)
- Bone Formation MarkersImproves (the measure goes up)
- PMS SymptomsImproves (the measure goes down)
Shop the evidence-backed picks
Manganese products we can link to, in the forms the graded studies used where we can match them.
- Grade B
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