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Condition

Chronic Mountain Sickness (CMS)

Chronic mountain sickness, or Monge's disease, develops over months or years at high altitude, when the body overproduces red blood cells to offset low oxygen. Iron has the strongest evidence among supplements, rated moderate across about 350 people, with vitamin D behind it at limited. Balance matters, since too much iron can push red cell counts higher, and the evidence for other options, including maca, is limited at best.

Supplements studied
1
Graded outcomes
1
Trials
1
People studied
197

Evidence by supplement

  • Strong
  • Moderate
  • Limited
  • Very limited

1 supplement

Maca: outcomes studied for Chronic Mountain Sickness (CMS)
GradeOutcomeEffectSizeStudiesPeopleStudies list
Blood glucose

No effect

NoneNo effect197 people
Chronic Mountain Sickness SymptomsImproves (the measure goes down)1 study197 people
LibidoImproves (the measure goes up)1 study197 people
Blood PressureImproves (the measure goes down)197 people
Fatigue SymptomsImproves (the measure goes down)197 people
HemoglobinImproves (the measure goes up)197 people
Quality of LifeImproves (the measure goes up)197 people
Subjective Well-BeingImproves (the measure goes up)197 people

Key findings

  • Blood glucoseMaca

The Chronic Mountain Sickness Support protocol

2 primary supplements · 7 supporting supplements

  • IronOnly if ferritin low (<20); goal is normal iron stores, not excess
  • Vitamin D2,000–4,000 IU daily

See the full protocol

Shop the evidence-backed picks

Support alongside medical care. These supplements are not a treatment for Chronic Mountain Sickness (CMS). If you are being treated for it, talk to your clinician before adding one: supplements can interact with medicines.

Fullscript collectionMuscle, performance and healthy ageing: evidence-graded picksOpen on Fullscript

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Studies cited

2 studies from PubMed

  1. A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmenJ Ethnopharmacol · PMID 19781622
  2. Acceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled StudyPharmaceuticals · PMID 27548190