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A-Grade Evidence

These pairs of a supplement (or a medicine or peptide) and a condition have the strongest scientific evidence: multiple high-quality studies with consistent results.

Type 2 Diabetes3 supplements · 8 medicines and peptides
Red Yeast Rice
4 outcomes
Beta-glucans
3 outcomes
Black Seed Oil
2 outcomes

Prescription medicines and peptides, for context

Exenatide (Byetta/Bydureon)
6 outcomes
Dulaglutide (Trulicity)
5 outcomes
Lixisenatide (Adlyxin)
5 outcomes
Pramlintide (Symlin)
5 outcomes
Tirzepatide (Mounjaro/Zepbound)
5 outcomes
Liraglutide (Victoza/Saxenda)
4 outcomes
Semaglutide (Ozempic/Wegovy)
3 outcomes
Retatrutide (GLP-3 Triple Agonist)
1 outcome
Obesity1 supplement · 5 medicines and peptides
Triphala (Emblica officinalis, Terminalia chebula, Terminalia bellirica)
1 outcome

Prescription medicines and peptides, for context

Setmelanotide (Imcivree)
5 outcomes
Semaglutide (Ozempic/Wegovy)
4 outcomes
Tirzepatide (Mounjaro/Zepbound)
4 outcomes
Liraglutide (Victoza/Saxenda)
3 outcomes
Retatrutide (GLP-3 Triple Agonist)
3 outcomes
Bone Health2 supplements · 4 medicines and peptides
Vitamin K2 (MK-7)
5 outcomes
Strontium
3 outcomes

Prescription medicines and peptides, for context

Calcitonin Salmon
3 outcomes
Romosozumab (Evenity)
2 outcomes
Denosumab (Prolia/Xgeva)
1 outcome
Sermorelin
1 outcome
Osteoporosis5 medicines and peptides

Prescription medicines and peptides, for context

Denosumab (Prolia/Xgeva)
6 outcomes
Romosozumab (Evenity)
6 outcomes
Teriparatide (Forteo)
6 outcomes
Abaloparatide
5 outcomes
Calcitonin Salmon
3 outcomes
Prostate Cancer5 medicines and peptides

Prescription medicines and peptides, for context

Degarelix (Firmagon)
5 outcomes
Goserelin (Zoladex)
3 outcomes
Histrelin (Vantas/Supprelin)
3 outcomes
Leuprolide (Lupron)
3 outcomes
Triptorelin (Trelstar)
3 outcomes
Metabolic Health1 supplement · 4 medicines and peptides
Beta-glucans
1 outcome

Prescription medicines and peptides, for context

Sermorelin
3 outcomes
MOTS-c
2 outcomes
Tesamorelin
2 outcomes
Ipamorelin
1 outcome
Candidemia and Invasive Candidiasis4 medicines and peptides

Prescription medicines and peptides, for context

Micafungin (Mycamine)
5 outcomes
Anidulafungin
4 outcomes
Caspofungin (Cancidas)
4 outcomes
Rezafungin (Rezzayo)
4 outcomes
Acromegaly4 medicines and peptides

Prescription medicines and peptides, for context

Pegvisomant (Somavert)
5 outcomes
Lanreotide (Somatuline)
3 outcomes
Octreotide (Sandostatin)
3 outcomes
Pasireotide (Signifor)
2 outcomes
High Cholesterol4 supplements
Citrus Bergamot (Bergamot Polyphenolic Fraction)
4 outcomes
Black Seed Oil
3 outcomes
Beta-glucans
2 outcomes
Triphala (Emblica officinalis, Terminalia chebula, Terminalia bellirica)
1 outcome
Skin and Soft Tissue Infections4 medicines and peptides

Prescription medicines and peptides, for context

Dalbavancin (Dalvance)
4 outcomes
Oritavancin (Orbactiv)
4 outcomes
Daptomycin (Cubicin)
3 outcomes
Telavancin (Vibativ)
2 outcomes
Multiple Myeloma3 medicines and peptides

Prescription medicines and peptides, for context

Bortezomib
6 outcomes
Carfilzomib (Kyprolis)
5 outcomes
Motixafortide (Aphexda)
4 outcomes
Depression3 supplements
Curcumin
6 outcomes
Fish Oil
2 outcomes
St. John's Wort
1 outcome
Chronic Venous Insufficiency3 supplements
Horse Chestnut
5 outcomes
Diosmin
4 outcomes
Gotu Kola
4 outcomes
Infertility3 medicines and peptides

Prescription medicines and peptides, for context

Cetrorelix (Cetrotide)
4 outcomes
Ganirelix (Antagon/Orgalutran)
4 outcomes
Kisspeptin-54
4 outcomes
Neuroendocrine Tumors3 medicines and peptides

Prescription medicines and peptides, for context

Lanreotide (Somatuline)
4 outcomes
Lutetium-177 Dotatate (Lutathera)
4 outcomes
Octreotide (Sandostatin)
4 outcomes
Cardiovascular Disease3 medicines and peptides

Prescription medicines and peptides, for context

Dulaglutide (Trulicity)
3 outcomes
Liraglutide (Victoza/Saxenda)
3 outcomes
Semaglutide (Ozempic/Wegovy)
3 outcomes
Breast Cancer1 supplement · 2 medicines and peptides
Laughter
3 outcomes

Prescription medicines and peptides, for context

Goserelin (Zoladex)
3 outcomes
Triptorelin (Trelstar)
3 outcomes
Premenstrual Syndrome (PMS)2 supplements
Chaste tree
10 outcomes
Lemon Balm
2 outcomes
Cardiovascular Health2 supplements
Aged Garlic Extract
8 outcomes
Salt
1 outcome
Multidrug-Resistant Bacterial Infections2 medicines and peptides

Prescription medicines and peptides, for context

Colistin (Polymyxin E)
5 outcomes
Polymyxin B
5 outcomes
Hereditary Angioedema2 medicines and peptides

Prescription medicines and peptides, for context

Icatibant (Firazyr)
5 outcomes
Ecallantide (Kalbitor)
4 outcomes
Blood Health2 medicines and peptides

Prescription medicines and peptides, for context

Pegcetacoplan (Empaveli)
5 outcomes
Gramicidin
1 outcome
Percutaneous Coronary Intervention2 medicines and peptides

Prescription medicines and peptides, for context

Bivalirudin
4 outcomes
Eptifibatide (Integrilin)
1 outcome
Bone Cancer2 medicines and peptides

Prescription medicines and peptides, for context

Mifamurtide (Mepact)
4 outcomes
Denosumab (Prolia/Xgeva)
1 outcome
Endometriosis2 medicines and peptides

Prescription medicines and peptides, for context

Nafarelin (Synarel)
4 outcomes
Leuprolide (Lupron)
3 outcomes
Pregnancy and Delivery Health1 supplement · 1 medicine or peptide
Vitamin D
2 outcomes

Prescription medicines and peptides, for context

Oxytocin (Pitocin)
4 outcomes
Irritable Bowel Syndrome (IBS)2 supplements
Peppermint
4 outcomes
Melatonin
3 outcomes
General Gut Health2 supplements
Psyllium
4 outcomes
Resistant Starch
2 outcomes
Digestive Health2 supplements
Psyllium
3 outcomes
Senna
2 outcomes
Pancreatitis2 medicines and peptides

Prescription medicines and peptides, for context

Secretin (ChiRhoStim)
3 outcomes
Sincalide (Kinevac)
1 outcome
Osteoarthritis (OA)1 supplement · 1 medicine or peptide
Systemic Enzymes (Bromelain/Trypsin/Rutin)
3 outcomes

Prescription medicines and peptides, for context

Retatrutide (GLP-3 Triple Agonist)
1 outcome
Acute Respiratory Infection (ARI)1 supplement · 1 medicine or peptide
Zinc
3 outcomes

Prescription medicines and peptides, for context

Telavancin (Vibativ)
2 outcomes
Early-Onset Puberty2 medicines and peptides

Prescription medicines and peptides, for context

Histrelin (Vantas/Supprelin)
2 outcomes
Nafarelin (Synarel)
1 outcome
Constipation2 medicines and peptides

Prescription medicines and peptides, for context

Linaclotide (Linzess)
2 outcomes
Plecanatide (Trulance)
2 outcomes
Constipation-Predominant Irritable Bowel Syndrome (IBS-C)2 medicines and peptides

Prescription medicines and peptides, for context

Linaclotide (Linzess)
2 outcomes
Plecanatide (Trulance)
2 outcomes
Preeclampsia2 supplements
Vitamin D
2 outcomes
Calcium
1 outcome
High Blood Pressure2 supplements
Roselle
1 outcome
Roselle
1 outcome
Aerobic Exercise Performance1 supplement
Caffeine
15 outcomes
Hepatic Encephalopathy1 supplement
L-Carnitine
11 outcomes
Cycling Performance1 supplement
Caffeine
10 outcomes
Lactose Intolerance1 supplement
Lactase Enzyme
10 outcomes
Acute Bronchitis1 supplement
Umckaloabo
10 outcomes
Anaerobic Exercise Performance1 supplement
Caffeine
8 outcomes
H. Pylori Infection1 supplement
Probiotics
8 outcomes
Chemotherapy Side Effects1 supplement
Probiotics
7 outcomes
Common Cold1 supplement
Umckaloabo
7 outcomes
Anxiety Disorders (Other)1 supplement
Kava
6 outcomes
Preterm Labor1 medicine or peptide

Prescription medicines and peptides, for context

Atosiban
5 outcomes
Allergic Rhinitis (Seasonal Allergies / Hay Fever)1 supplement
Black seed
5 outcomes
HIV Infection1 medicine or peptide

Prescription medicines and peptides, for context

Enfuvirtide (Fuzeon)
5 outcomes
Secondary Hyperparathyroidism1 medicine or peptide

Prescription medicines and peptides, for context

Etelcalcetide (Parsabiv)
5 outcomes
Heart Failure1 medicine or peptide

Prescription medicines and peptides, for context

Nesiritide (Natrecor)
5 outcomes
Short Bowel Syndrome (SBS)1 medicine or peptide

Prescription medicines and peptides, for context

Teduglutide (Gattex)
5 outcomes
Lupus Nephritis1 medicine or peptide

Prescription medicines and peptides, for context

Voclosporin (Lupkynis)
5 outcomes
Chronic pain1 medicine or peptide

Prescription medicines and peptides, for context

Ziconotide (Prialt)
5 outcomes
Septic Shock1 medicine or peptide

Prescription medicines and peptides, for context

Angiotensin II
4 outcomes
Hypoadrenalism1 medicine or peptide

Prescription medicines and peptides, for context

Cosyntropin (Cortrosyn/Synacthen)
4 outcomes
Barth Syndrome1 medicine or peptide

Prescription medicines and peptides, for context

Elamipretide (Forzinity/SS-31)
4 outcomes
Severe Hypoglycemia1 medicine or peptide

Prescription medicines and peptides, for context

Glucagon (GlucaGen/Gvoke/Baqsimi)
4 outcomes
Hypogonadotropic Hypogonadism1 medicine or peptide

Prescription medicines and peptides, for context

Gonadorelin (Factrel)
4 outcomes
Renal Anemia1 medicine or peptide

Prescription medicines and peptides, for context

Peginesatide (Omontys)
4 outcomes
Hypoactive Sexual Desire Disorder1 medicine or peptide

Prescription medicines and peptides, for context

PT-141 (Bremelanotide)
4 outcomes
Immune Thrombocytopenia1 medicine or peptide

Prescription medicines and peptides, for context

Romiplostim (Nplate)
4 outcomes
Hepatorenal Syndrome1 medicine or peptide

Prescription medicines and peptides, for context

Terlipressin (Terlivaz)
4 outcomes
Vasodilatory Shock1 medicine or peptide

Prescription medicines and peptides, for context

Vasopressin (Vasostrict/Pitressin)
4 outcomes
Achondroplasia1 medicine or peptide

Prescription medicines and peptides, for context

Vosoritide (Voxzogo)
4 outcomes
Photodermatoses1 medicine or peptide

Prescription medicines and peptides, for context

Afamelanotide
3 outcomes
Cushing's Syndrome1 medicine or peptide

Prescription medicines and peptides, for context

Corticorelin Ovine (Acthrel)
3 outcomes
Chronic Low Back Pain1 supplement
Devil's Claw (Harpagophytum procumbens)
3 outcomes
Chronic Kidney Disease-Associated Pruritus1 medicine or peptide

Prescription medicines and peptides, for context

Difelikefalin (Korsuva)
3 outcomes
Acute Coronary Syndrome (ACS)1 medicine or peptide

Prescription medicines and peptides, for context

Eptifibatide (Integrilin)
3 outcomes
Morning Sickness1 supplement
Ginger (Zingiber officinale)
3 outcomes
Neurological Health1 medicine or peptide

Prescription medicines and peptides, for context

Humanin
3 outcomes
Stress1 supplement
Kava
3 outcomes
Subfertility1 medicine or peptide

Prescription medicines and peptides, for context

Kisspeptin-54
3 outcomes
Iron Deficiency Anemia1 supplement
Lactoferrin
3 outcomes
Cancer-Related Fatigue1 supplement
Laughter
3 outcomes
Gastrointestinal Cancer1 supplement
Laughter
3 outcomes
General Cancer Care and Prevention1 supplement
Laughter
3 outcomes
Lung Cancer1 supplement
Laughter
3 outcomes
Growth Hormone Deficiency1 medicine or peptide

Prescription medicines and peptides, for context

Macimorelin (Macrilen)
3 outcomes
Molybdenum Deficiency1 supplement
Molybdenum
3 outcomes
Acne1 supplement
Nicotinamide
3 outcomes
Cushing's Disease1 medicine or peptide

Prescription medicines and peptides, for context

Pasireotide (Signifor)
3 outcomes
Central Hypothyroidism1 medicine or peptide

Prescription medicines and peptides, for context

Protirelin (TRH)
3 outcomes
Peripheral T-Cell Lymphoma1 medicine or peptide

Prescription medicines and peptides, for context

Romidepsin (Istodax)
3 outcomes
Biliary Dyskinesia1 medicine or peptide

Prescription medicines and peptides, for context

Sincalide (Kinevac)
3 outcomes
Respiratory Health1 medicine or peptide

Prescription medicines and peptides, for context

Tyrothricin
3 outcomes
Copper Deficiency1 supplement
Copper
2 outcomes
Mucositis1 supplement
Curcumin
2 outcomes
Staphylococcal Bacteremia and Endocarditis1 medicine or peptide

Prescription medicines and peptides, for context

Daptomycin (Cubicin)
2 outcomes
Central Diabetes Insipidus1 medicine or peptide

Prescription medicines and peptides, for context

Desmopressin (DDAVP)
2 outcomes
Hemophilia1 medicine or peptide

Prescription medicines and peptides, for context

Desmopressin (DDAVP)
2 outcomes
Nocturnal Enuresis1 medicine or peptide

Prescription medicines and peptides, for context

Desmopressin (DDAVP)
2 outcomes
Insomnia1 supplement
Melatonin
2 outcomes
Cutaneous T-Cell Lymphoma1 medicine or peptide

Prescription medicines and peptides, for context

Romidepsin (Istodax)
2 outcomes
Schizophrenia1 supplement
Sarcosine
2 outcomes
Zollinger-Ellison Syndrome1 medicine or peptide

Prescription medicines and peptides, for context

Secretin (ChiRhoStim)
2 outcomes
Appetite Regulation1 medicine or peptide

Prescription medicines and peptides, for context

Setmelanotide (Imcivree)
2 outcomes
Cognitive Improvement1 supplement
Tea (Camellia sinensis)
2 outcomes
Variceal Bleeding1 medicine or peptide

Prescription medicines and peptides, for context

Terlipressin (Terlivaz)
2 outcomes
Body Composition1 medicine or peptide

Prescription medicines and peptides, for context

Tesamorelin
2 outcomes
Nonalcoholic Fatty Liver Disease (NAFLD)1 medicine or peptide

Prescription medicines and peptides, for context

Tesamorelin
2 outcomes
B5 Deficiency1 supplement
Vitamin B5 (Pantothenic Acid)
2 outcomes
Fall Prevention1 supplement
Vitamin D
2 outcomes
Skin Health1 medicine or peptide

Prescription medicines and peptides, for context

Afamelanotide
1 outcome
Kidney Health1 medicine or peptide

Prescription medicines and peptides, for context

Bacitracin
1 outcome
Epilepsy1 supplement
Cannabidiol (CBD)
1 outcome
Arsenic Poisoning1 supplement
Charcoal
1 outcome
Hemorrhoids1 supplement
Diosmin
1 outcome
Surgical Recovery1 supplement
Ginger (Zingiber officinale)
1 outcome
Celiac Disease1 supplement
Gluten
1 outcome
Hair Loss1 supplement
Minoxidil
1 outcome
Parkinson's Disease1 supplement
Mucuna Pruriens
1 outcome
Type 1 Diabetes1 medicine or peptide

Prescription medicines and peptides, for context

Pramlintide (Symlin)
1 outcome
Fatty Liver Disease1 medicine or peptide

Prescription medicines and peptides, for context

Retatrutide (GLP-3 Triple Agonist)
1 outcome
General Oral Health1 supplement
Triphala (Emblica officinalis, Terminalia chebula, Terminalia bellirica)
1 outcome
General Health1 medicine or peptide

Prescription medicines and peptides, for context

Tyrothricin
1 outcome
Acute Respiratory Distress Syndrome1 medicine or peptide

Prescription medicines and peptides, for context

Vasoactive Intestinal Peptide (VIP/Aviptadil)
1 outcome